Selective sequestration and metabolism of plant derived pyrrolizidine alkaloids by chrysomelid leaf beetles

Hartmann, Thomas; Witte, Ludger; Ehmke, Adelheid; Theuring, Claudine; Rowell‐Rahier, Martine; Pasteels, Jacques

doi:10.1016/s0031-9422(97)00009-5

Cited by 58 publications

(49 citation statements)

References 23 publications

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“…Oreina cacaliae and O. speciosissima have chemical defences (Hartmann et al, 1997) and are aposematic. They show considerable colour polymorphism.…”

Section: Natural History Of the Beetlesmentioning

confidence: 99%

Distribution of genetic variance and isolation by distance in two leaf beetle species: Oreina cacaliae and Oreina speciosissima

Knoll

Rowell‐Rahier

1998

Heredity

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The distribution of genetic variance was investigated in two closely related Oreina leaf beetle species, Oreina cacaliae and Oreina speciosissima. Populations of these alpine beetles were sampled in mountainous areas of Western Europe, the total sampling area ranging from the Pyrenees to the Czech Republic. Allozyme electrophoresis of 21 (O. cacaliae) and 16 (O. speciosissima) loci revealed high genetic variability as expressed in a high percentage of polymorphic loci (only one monomorphic locus was found in each species) and high heterozygosities. No overall linkage disequilibrium was found in either species. Extensive heterozygote deficits were observed in several samples as reflected by high F IS -values and high overall inbreeding coefficients (F IT ) of 0.349 (O. cacaliae) and 0.503 (O. speciosissima). The overall inbreeding coefficient was mainly attributable to within-population differentiation. The high heterozygote deficits are explained by a combination of inbreeding resulting in kinship groups and a sampling effect over several such kinship groups. No explanation of the observed patterns could be found in the host plant use or altitudinal location of the samples. For O. cacaliae, isolation by distance was found, but not for O. speciosissima. Gene flow estimates were in the range of Nm = 0.8 to 1.5.

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“…Oreina cacaliae and O. speciosissima have chemical defences (Hartmann et al, 1997) and are aposematic. They show considerable colour polymorphism.…”

Section: Natural History Of the Beetlesmentioning

confidence: 99%

Distribution of genetic variance and isolation by distance in two leaf beetle species: Oreina cacaliae and Oreina speciosissima

Knoll

Rowell‐Rahier

1998

Heredity

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“…4) . Koanophyllon is closely related to the genus Eupatorium known to contain PAs of the lycopsamine type (Hartmann & Witte 1995). A re-examination of various plant organs from newly collected plant materials confirmed the presence of isoretronecanol and trachelanthamidine in leaves and inflorescences, but in addition, the latter were found to contain trace amounts of rinderine and lycopsamine.…”

Section: Pyrrolizidine Alkaloids In Koanophyllon Panamense and Its Lementioning

confidence: 90%

“…Oreina species feeding on Adenostyles alliariae and Senecio nemorensis (Asteraceae, tribe Senecioneae) which contain macrocyclic pyrrolizidine alkaloids of the senecionine type (Hartmann & Witte 1995) accumulate these alkaloids in addition to cardenolides in their defensive secretions (Pasteels et al 1988, Rowell-Rahier et al 1991. The host plants contain PAs in the state of their non-toxic N-oxides (for details see Hartmann 1999) which are absorbed as such by the beetles and stored in the hemolymph and solid body-tissues.…”

Section: Introductionmentioning

confidence: 99%

“…The host plants contain PAs in the state of their non-toxic N-oxides (for details see Hartmann 1999) which are absorbed as such by the beetles and stored in the hemolymph and solid body-tissues. The body compartment functions as a reservoir that replenishes the exocrine glands where the PA N-oxides are concentrated and released with the defensive secretions in quantities up to 0.3 mol l -1 , Hartmann et al 1997). Host-plant PAs entering the beetle's body as pro-toxic tertiary alkaloid are detoxified by glucosylation .…”

Section: Introductionmentioning

confidence: 99%

“…The known species of the vast genus Platyphora are specialized to single host plants out of six plant families , Termonia et al 2002. Among these taxa, there are three families (i.e., Asteraceae tribe Eupatorieae, Apocynaceae and Boraginaceae) which share the ability to synthesize unique open-chain monoester PAs of the lycopsamine type (Hartmann & Witte 1995, Hartmann & Ober 2000. All the Platyphora species specialized to alkaloid-containing species out of these families are capable of sequestering PAs of the lycopsamine type and accumulating them along with the saponins in their exocrine defensive secretions .…”

Section: Introductionmentioning

confidence: 99%

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Uptake and metabolism of [ 14 C]rinderine and [ 14 C]retronecine in leaf-beetles of the genus Platyphora and alkaloid accumulation in the exocrine defensive secretions

et al. 2003

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Summary. Sequestration and processing of pyrrolizidine alkaloids (PAs) by leaf beetles of the genus Platyphora were investigated. Tracer experiments with labeled alkaloids were performed with P. eucosma feeding on Koanophyllon panamense (Asteraceae, tribe Eupatorieae). P. eucosma catalyzes the same reactions previously demonstrated for P. boucardi specialized to Prestonia portobellensis (Apocynaceae): (i) epimerization of rinderine to intermedine; (ii) esterification of retronecine yielding insect-specific PAs; (iii) efficient transport of the PAs as free bases into the defensive secretions. P. bella feeding on Tournefortia cuspidata (Boraginaceae) shows the same sequestration behavior and ability to synthesize the specific retronecine esters. P. ligata, a species phylogenetically closely related to the PA adapted species and clustering in the same clade, but feeding on a host plant devoid of PAs, feeds easily on PA treated hostplant leaves, but does not sequester or metabolize PAs. P. kollari a species clustering outside the PA clade refused to feed on its food-plant leaves painted with PAs. The results are discussed in relation to host-plant selection of the PA adapted species and the role of PAs in chemical defense.

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Biosynthesis of Defensive Compounds from Beetles and Ants

et al. 2003

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Many beetle and ant species owe their protection against predators to the presence of defensive compounds in their hemolymph or in specialized exocrine glands. A growing number of studies devoted to the elucidation of the biosynthetic pathways used by the insects to produce these compounds have been reported in recent years. An overview of these studies is presented. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

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Selective sequestration and metabolism of plant derived pyrrolizidine alkaloids by chrysomelid leaf beetles

Cited by 58 publications

References 23 publications

Distribution of genetic variance and isolation by distance in two leaf beetle species: Oreina cacaliae and Oreina speciosissima

Distribution of genetic variance and isolation by distance in two leaf beetle species: Oreina cacaliae and Oreina speciosissima

Uptake and metabolism of [ 14 C]rinderine and [ 14 C]retronecine in leaf-beetles of the genus Platyphora and alkaloid accumulation in the exocrine defensive secretions

Biosynthesis of Defensive Compounds from Beetles and Ants

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