Selective separation and characterisation of stress degradation products and process impurities of prucalopride succinate by LC-QTOF-MS/MS

Integrated resonance Rayleigh scattering approach utilizing Box–Behnken experimental design for the facile quantification of prucalopride in pharmaceutical tablets and human urine with sustainability assessment

“…According to the literature, the quantication of PCP was accomplished through the utilization of separation methodologies, specically high-performance liquid chromatography (HPLC). [3][4][5][6] Electro-analytical techniques, such as voltammetry 7 and potentiometry 8 were also employed for its estimation. The reported chromatographic and electrochemical methods required tedious sample pretreatment steps, less green and expensive solvents and sophisticated instruments.…”

Bioanalytical Validated Spectrofluorimetric Method for the Determination of Prucalopride succinate in Human Urine Samples and Its Greenness Evaluation

“…The literature review revealed the determination of PRU using various analytical techniques including chromatographic [4][5][6][7][8][9][10], spectrophotometric [11] methods and only one reported spectrofluorometric procedure that uses luminescence reaction [12] but there is no quantification in the urine sample. Spectrofluorimetric technique is commonly used in drugs analysis either in dosage form or in biological fluids for its high sensitivity and simplicity [13][14][15].…”

Sensitive spectrofluorimetric determination of the prokinetic drug prucalopride succinate based on supramolecular aggregation approach with evaluation of method greenness: application to content uniformity test

“…For PCP analysis, literature reports document few spectrophotometric methods [3][4][5][6][7], spectrofluorimetric methods [8][9][10][11], chromatographic methods [12][13][14][15], and electrochemical methods [16,17]. The reported spectrophotometric methods had limited sensitivity.…”