Selective BET inhibitor RVX‐208 ameliorates periodontal inflammation and bone loss
Mingxu Sun,
Nicholas Clayton,
Sheikh Alam
et al.
Abstract:AimTo determine the effects of RVX‐208, a selective bromodomain and extra‐terminal domain (BET) inhibitor targeting bromodomain 2 (BD2), on periodontal inflammation and bone loss.Materials and MethodsMacrophage‐like cells (RAW264.7) and human gingival epithelial cells were challenged by Porphyromonas gingivalis (Pg) with or without RVX‐208. Inflammatory gene expression and cytokine production were measured by reverse transcription polymerase chain reaction and enzyme‐linked immunosorbent assay, respectively. R… Show more
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