Selective removal of cholesterol esters in an arteriosclerotic region of blood vessels with a free-electron laser

Mid-IR super-continuum generation

“…Mid-IR absorption spectra of the atherosclerotic plaque components, including adipose tissue, macrophages and foam cells, have been measured by both a lamp based [22] and a synchrotron laser [23] based FTIR system. On the other hand, single wavelength-dependent selective ablation has been performed in 5.75 μm to 6.1 μm for ablation of cholesterol esters using free-electron laser [24]. In comparison, our all-fiber-integrated light source has been packaged into a 2U rack unit (19 inches in width/21 inches in depth/4 inches in height), and the MIRFIL could be potentially deployed in the clinical environment for practical medical use.…”

Infrared Free Electron Laser Induced Angioplasty for Arteriosclerotic Region of Blood Vessels

“…Answers to these questions may vary depending on the incident macropulse power, E M , and thickness of the normal tissue, D. We briefly estimated the conditions to satisfy these points, using the properties of water for the upper soft normal tissue, of which as much as 80 wt% is water. Here we ignored the absorption of protein, one more main element of normal tissue, since there is little absorption of protein at the wavelength of 5.75 µm 10) .…”

“…In order to minimize the side effects, we have employed mid infrared free electron lasers 9) (MIRFELs) [10][11][12][13] . The sharp absorption peaks of many materials are distributed in the MIR region, allowing selective targeting by altering the wavelength.…”

Bilirubin Calculi Crushing by Laser Irradiation at a Molecular Oscillating Region Wavelength Based on Infrared Absorption Spectrum Analysis Using a Free-Electron Laser: An Experimental Study

“…Awazu et al also demonstrated that a FEL adjusted to a wavelength of 5.75 µm, which is what we selected in the present study, causes absolutely no changes to human albumin and the vascular walls. 33 This indicates that direct injury from laser irradiation of the bile duct wall is unlikely to occur, and that injuries to the surrounding tissue, such as hemorrhaging and perforations, can also be avoided.…”