Selective refueling of CAR T cells using ADA1 and CD26 boosts antitumor immunity

Hu, Yue; Sarkar, Abhijit; Song, Kevin; Michael, Sara; Hook, Magnus; Wang, Ruoning; Heczey, Andras; Song, Xiaotong

doi:10.1016/j.xcrm.2024.101530

Cell Reports Medicine

2024

DOI: 10.1016/j.xcrm.2024.101530

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Selective refueling of CAR T cells using ADA1 and CD26 boosts antitumor immunity

Yue Hu,

Abhijit Sarkar,

Kevin Song

et al.

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2024

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References 78 publications

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Advances in research on factors affecting chimeric antigen receptor T‐cell efficacy

Zhou,

Zhu,

Xiao

2024

Cancer Medicine

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Chimeric antigen receptor T‐cell (CAR‐T) therapy is becoming an effective technique for the treatment of patients with relapsed/refractory hematologic malignancies. After analyzing patients with tumor progression and sustained remission after CAR‐T cell therapy, many factors were found to be associated with the efficacy of CAR‐T therapy. This paper reviews the factors affecting the effect of CAR‐T such as tumor characteristics, tumor microenvironment and immune function of patients, CAR‐T cell structure, construction method and in vivo expansion values, lymphodepletion chemotherapy, and previous treatment, and provides a preliminary outlook on the corresponding therapeutic strategies.

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Advances in research on factors affecting chimeric antigen receptor T‐cell efficacy

Zhou,

Zhu,

Xiao

2024

Cancer Medicine

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show abstract

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Selective refueling of CAR T cells using ADA1 and CD26 boosts antitumor immunity

Cited by 1 publication

References 78 publications

Advances in research on factors affecting chimeric antigen receptor T‐cell efficacy

Advances in research on factors affecting chimeric antigen receptor T‐cell efficacy

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