Selective recognition of consecutive G sequence in double-stranded DNA by a Zinc(II)–macrocyclic tetraamine complex appended with an anthraquinone

Interaction of bis-aryl functionalized molecules with nucleosides and nucleic acids

“…As shown in Figure 5(a), Job's plot indicates that the receptor 1b can form 1:1 complex with cytidine. It is well known that the Zinc complex of cyclen is able to recognize some of the nucleosides or similar derivatives [41][42][43][44]. To find out the binding site of this type of compounds, zinc ions were introduced and the stoichiometry of the Zn(II) complex was also measured.…”

Cleavage of an RNA analog by Zn(II) macrocyclic catalysts appended with a methyl or an acridine group

“…This complex exhibits enhanced binding to di or trinucleotides containing uridine or guanosine [30] in a binding interaction that is enhanced by stacking of the nucleobase on the acridine in conjunction with Zn(II) binding to uridine N3 or guanosine N7 [50]. Not surprizingly however, the sequence-specific binding of this complex to double-stranded DNA or RNA is different than that observed in single-stranded oligonucleotides [51]. Such complexes that contain multiple recognition groups have many potential binding interactions with structured nucleic acids and, depending on the nucleic acid structure, one recognition group may dominate over the other and determine the binding mode.…”

Mono- and Dinuclear Copper(II) Complexes of Pendant-Arm Macrocyclic Polyamines: Synthesis, Characterization and Investigation as Hydrolytic Cleavage Agents for DNA

“…For small coordination compounds that act hydrolytically as chemical nucleases, DNA site selectivity is left relatively unreported in the literature [59,70,71] although saturated polydentate complexes generally, while not ideal for high DNA cleavage activity, may be appropriate for interaction with DNA that leads to specific binding or cleavage [72]. For small coordination compounds that act hydrolytically as chemical nucleases, DNA site selectivity is left relatively unreported in the literature [59,70,71] although saturated polydentate complexes generally, while not ideal for high DNA cleavage activity, may be appropriate for interaction with DNA that leads to specific binding or cleavage [72].…”