Selective Recognition and Quantification of 2,3‐Bisphosphoglycerate in Human Blood Samples by a Rhodamine Derivative

Abstract

An ew chemosensing ensemble of an azo-based rhodamine derivative (probe 1)w ith Hg 2 + for as elective and quantitative detectiono f2 ,3-bisphosphoglycerate (2,3-BPG), whichs hows as imple dual signal (color and "off-on-off" fluorescent change) in water,w as developed.To the best of our knowledge, this is the first known substituted rhodaminec onjugatew hich has been demonstrated to recognize 2,3-BPG in live cellsw ithin the detection limit of nanomolar range. A 1 HNMR titration has been carried out to determine the natureo ft he interaction between the probe 1-Hg 2 + complex and 2,3-BPG. The amount of 2,3-BPG in blood cells, that changes during anemia, hypoxiao rc hronic lungs disease, could be easily measured using the fluorescencep roperty of the probe 1-Hg 2 + complex.

A Multi‐Signaling Performance for Simultaneous Surveillance and Accretion of Cysteine and Serine in Human Cancer Cell

“…[28] In chemosensing ensemble methods, an indicator molecule is combined with other component(s), such a receptor or metal ion(s) through non-covalent interactions and enhanced or quenched the fluorescence of the indicator, have also been developed as potential techniques. [29] So far, many fluorescent probes have been reported to detect cystine but here we first time report a unique chemosensing method for the differential detection and accumulation of Cysteine and Serine in human cancer cell. Scheme 1 shows the structure of the designed probe DNPC and the corresponding chemosensing ensemble (DNPC-Cu 2 + ) and its possible interactions with Cys and Ser through a turn "on-off-on" mechanism.…”

Highly Selective Optical and Fluorescence “Turn On” Signaling of Al3+: Cell Imaging and Estimation in Rice Plant

“…In recent years certain analytical approaches have been reported for the detection and quantification of bio‐relevant metal ions, but many of them are associated with various crucial drawbacks . But chemosensors based on fluorescent and optical signaling method turn out to be a promising device owing to its remarkable selectivity and sensitivity, portability, low cost, instant responds, naked eye detection facilities to estimate metal ions in analytical, medical, environmental and biological fields . However the detection of Al is always challenging than the other metal ions due to its high hydration ability in water, poor coordination ability and lack of spectroscopic characterization, thus development of a simple but very precise chemosensor for Al detection is a significant domain of research.…”

Highly Selective and Sensitive 2‐(2′‐Hydroxyphenyl)benzothiazole‐Based Turn‐On Fluorescent Probes for Detecting and Imaging Bisulfite in Living Cells

“…Compared with conventional detection methods such as titration, [14] electrochemical methods, [15] spectrophotometry, [16] and chromatography, [17,18] fluorescentp robes have received considerable attention due to their simplicity,h igh selectivity, outstanding sensitivity,r apid response time and ability to provide in vivo fluorescencei maging. [19,20] In recent decades, numerous fluorescent probes for the detection of HSO 3 À have been developed. [21][22][23][24][25][26][27][28][29][30][31] Their sensing mechanisms are mainly based on nucleophilic addition, deprotection of levulinate and coordination to metal ions.…”