Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats

Sugiyama, Tomomi; Nagata, Junichi; Yamagishi, Azumi; Endoh, Kaori; Saito, Morio; Yamada, Kazuhiko; Yamada, Shizuo; Umegaki, Keizo

doi:10.1016/j.lfs.2005.09.025

Cited by 35 publications

(21 citation statements)

References 39 publications

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“…GPx is an important marker in protecting the liver from damage of lipid peroxidation. GPx is GSH related enzymes, which can catalyze the synthesis of GSH-S-transferase to ease the burden of lipid peroxidation [19,20]. Plant contains a wide variety of free radicals scavenging molecules including phenols, flavonoids, vitamins, terpenoids that are rich in antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Attribution of antibacterial and antioxidant activity of Cassia tora extract toward its growth promoting effect in broiler birds

Sahu¹,

Koley²,

Sahu³

2017

Vet World

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Aim:The study was conducted to evaluate the attribution of antibacterial and antioxidant activity of methanolic extract of Cassia tora toward its growth promoting effect in broiler birds.Materials and Methods:A limit test was conducted for C. tora extract in Wistar albino rats. Phytochemical screening of methanolic extract of leaves of C. tora was carried out. In-vitro antibacterial activity was measured by disc diffusion method. 1-day-old Ven Cobb broiler birds (n=90) were randomly allocated into three groups consisting of three replicates with 10 birds in each group. The birds of group T1 (Control) received basal diet, whereas birds of group T2 (Standard) received an antibiotic (Lincomycin at 0.05% in feed). The birds of group T3 (Test) received Cassia tora extract (CSE) at 0.4 g/L in drinking water in addition to basal diet. The treatment was given to birds of all the groups for 6 weeks. Antioxidant activity of C. tora was determined in blood of broiler birds. Cumulative body weight gain, feed intake, feed conversion ratio (FCR), dressing percent, and organ weight factor were evaluated to determine growth performance in broiler birds.Results:Phytochemicals in C. tora were screened. Sensitivity to Escherichia coli and resistant to Staphylococcus aureus and Pseudomonas aeruginosa was observed in in-vitro antibacterial activity test. At the end of 6th week, antioxidant activity reflected significantly (p≤0.05) lower level of erythrocyte malondialdehyde and higher levels of reduced glutathione (GSH) and GSH peroxidase in broiler birds of group T2 and T3 as compared to broiler of group T1. Mean cumulative body weight gain of birds of T2 and T3 were significantly (p≤0.05) higher as compared to T1. Mean FCR of birds of group T3 decreased significantly than group T1.Conclusion:Supplementation of C. tora leaves extract at 0.4 g/L in drinking water improved growth performance in broiler birds due to its antimicrobial and antioxidant activity. Therefore, it could be used as an alternative to antibiotic growth promoter in poultry ration.

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Section: Discussionmentioning

confidence: 99%

Attribution of antibacterial and antioxidant activity of Cassia tora extract toward its growth promoting effect in broiler birds

Sahu¹,

Koley²,

Sahu³

2017

Vet World

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“…The metabolized product from NDMA is directly toxic to the liver and subsequently enhances inflammatory cell response, whereas O. viverrini induces a host immune response, which enhances inflammatory cells surrounding the hepatic bile duct. In addition, turmeric decreases liver detoxification (cytochrome P450), leading to a reduction of toxic metabolite products from NDMA (Sugiyama et al 2006;Surh and Chun 2007;Choi et al 2008). Moreover, the present study shows the property of turmeric to enhance bile flow and gall bladder contraction through decreased direct bilirubin level, a result which is supported by Deters et al (2000).…”

Section: Discussionmentioning

confidence: 99%

Turmeric reduces inflammatory cells in hamster opisthorchiasis

et al. 2009

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The curcumin compound from turmeric is effective in the treatment of many inflammatory diseases. The aim of our present study was to evaluate the efficacy of turmeric on reducing the histopathological changes of hamster opisthorchiasis. Hamsters were infected with Opisthorchis viverrini and then administered turmeric. Using light microscopic observation, liver function tests for alanine transaminase (ALT), alkaline phosphatase, and direct bilirubin were investigated. The resulting histopathological changes show that turmeric has anti-inflammatory properties--during both N-nitrosodimethylamine administration and O. viverrini infection--by reducing the aggregation of inflammatory cells surrounding the hepatic bile ducts, which correlates with a decreased serum ALT level. The decrease in direct bilirubin levels in the hamsters treated with turmeric suggests that turmeric may enhance biliary contraction. The present study found that turmeric clearly reduces the inflammatory cells in hamster opisthorchiasis at an early stage. This finding may be connected with a reduction in the risk factors of cholangiocarcinoma development.

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“…A previous study demonstrated that curcumin does not alter the levels and activity of cytochrome P450 in the liver, except at high doses of ≥5 g/kg/day (56). Instead, CCl 4 caused a marked reduction in the activity of these isoenzymes, particularly of cytochrome P450 2E1 (CYP2E1), with the formation of high levels of free radicals.…”

Section: Hepatoprotective Actionmentioning

confidence: 97%

Biological and therapeutic activities, and anticancer properties of curcumin

Perrone

Ardito

Giannatempo

et al. 2015

Experimental and Therapeutic Medicine

257

186

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Abstract. Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant. Curcumin has been used extensively in Ayurvedic medicine, as it is nontoxic and exhibits a variety of therapeutic properties, including antioxidant, analgesic, anti-inflammatory and antiseptic activities. Recently, certain studies have indicated that curcumin may exert anticancer effects in a variety of biological pathways involved in mutagenesis, apoptosis, tumorigenesis, cell cycle regulation and metastasis. The present study reviewed previous studies in the literature, which support the therapeutic activity of curcumin in cancer. In addition, the present study elucidated a number of the challenges concerning the use of curcumin as an adjuvant chemotherapeutic agent. All the studies reviewed herein suggest that curcumin is able to exert anti-inflammatory, antiplatelet, antioxidative, hepatoprotective and antitumor activities, particularly against cancers of the liver, skin, pancreas, prostate, ovary, lung and head neck, as well as having a positive effect in the treatment of arthritis.

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Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats

Cited by 35 publications

References 39 publications

Attribution of antibacterial and antioxidant activity of Cassia tora extract toward its growth promoting effect in broiler birds

Attribution of antibacterial and antioxidant activity of Cassia tora extract toward its growth promoting effect in broiler birds

Turmeric reduces inflammatory cells in hamster opisthorchiasis

Biological and therapeutic activities, and anticancer properties of curcumin

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