Selective Procedural Memory Impairment but Preserved Declarative Memory in Spinocerebellar Ataxia Type 3

Elyoseph, Zohar; Mintz, Matti; Vakil, Eli; Zaltzman, Roy; Gordon, Carlos R.

doi:10.1007/s12311-019-01101-w

Cited by 6 publications

(14 citation statements)

References 59 publications

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“…In other studies, there were subtle differences between immediate and delayed auditory recall (δ = 0.80 vs. 0.90 [17] and δ = 0.94 vs. 0.88 [21], and 40% of patients showed impairment of both immediate and delayed auditory recall [18]). In contrast, another study reported more severe impairment of delayed than immediate recall (δ = 1.07 vs. = 1.44 [23]), while another found only delayed recall impairment [25]. The latter two studies employed a test with no semantic association between word lists, namely, the Rey Auditory Verbal Learning Test (RAVLT) [23,25].…”

Section: Episodic Memorymentioning

confidence: 98%

“…Finally, a total of 15 articles were included in this review. Eleven articles reported on the neurocognitive profile of SCA3 [15][16][17][18][19][20][21][22][23][24][25]. Two of them did not include HC [15,18].…”

Section: Data Extraction and Analysismentioning

confidence: 99%

“…While motor control is vital in most inhibition tests, baseline-adjusted scores revealed inhibition impairment in SCA3 is likely independent from motor impairment [23]. Garrard, 2008 [16] Klinke, 2010 [17] Saute, 2010 [24] Schmitz-Hübsch, 2011 [25] Braga-Neto, 2012 [18] Lopes, 2013 [19] Ma, 2014 [20] Feng, 2014 [21] Lo, 2016 [26] Lin, 2018 [27] Tamura, 2018 [22] Elyoseph, 2020 [23] Green circle, low risk; yellow circle, unclear: cannot determine, not applicable, or not reported; red circle, high risk 2002 [13] (n = 6) Bürk, 2003 [14] (n = 11) Kawai, 2004 [15] (n = 16)…”

Section: Inhibitionmentioning

confidence: 99%

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Neurocognitive Changes in Spinocerebellar Ataxia Type 3: A Systematic Review with a Narrative Design

et al. 2021

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Spinocerebellar ataxia type 3 (SCA3), the commonest dominantly inherited ataxia worldwide, is characterized by disruption in the cerebellar-cerebral and striatal-cortical networks. Findings on SCA3-associated cognitive impairments are mixed. The classification models, tests and scoring systems used, language, culture, ataxia severity, and depressive symptoms are all potential confounders in neuropsychological assessments and may have contributed to the heterogeneity of the neurocognitive profile of SCA3. We conducted a systematic review of studies evaluating neurocognitive function in SCA3 patients. Of 1304 articles identified, 15 articles met the eligibility criteria. All articles were of excellent quality according to the National Institutes of Health quality assessment tool for casecontrol studies. In line with the disrupted cerebellar-cerebral and striatal-cortical networks in SCA3, this systematic review found that the neurocognitive profile of SCA3 is characterized by a core impairment of executive function that affects processes such as nonverbal reasoning, executive aspects of language, and recall. Conversely, neurocognitive domains such as general intelligence, verbal reasoning, semantic aspect of language, attention/processing speed, recognition, and visuospatial perception and construction are relatively preserved. This review highlights the importance of evaluating neurocognitive function in SCA3 patients. Considering the negative impact of cognitive and affective impairment on quality of life, this review points to the profound impairments that existing or future treatments should prioritize.

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Section: Episodic Memorymentioning

confidence: 98%

Section: Data Extraction and Analysismentioning

confidence: 99%

Section: Inhibitionmentioning

confidence: 99%

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Neurocognitive Changes in Spinocerebellar Ataxia Type 3: A Systematic Review with a Narrative Design

et al. 2021

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“…Several studies show that SCA3 patients have deficits with immediate auditory recall and delayed auditory recall ( Bürk et al, 2003 ; Kawai et al, 2004 ; Garrard et al, 2008 ; Lopes et al, 2013 ; Feng et al, 2014 ; Ma et al, 2014 ; Tamura et al, 2018 ). A single study shows impairment of delayed recall but average immediate recall ( Elyoseph et al, 2020 ). Deficits in both immediate and delayed recall in visual episodic memory were identified with the Visual Paired Associate test, and delayed recall in visual episodic memory was detected with the Visual Reproduction test.…”

Section: Methodsmentioning

confidence: 99%

“…Problems with recall are due to impairments of executive functions. A study shows contrasting results for procedural learning, where SCA3 patients have impaired procedural learning of the sensory-motor sequence on the procedural Serial Reaction Time Test but regular learning on the procedural Weather Prediction Probabilistic Classification test ( Elyoseph et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Neurocognitive and cerebellar function in ADHD, autism and spinocerebellar ataxia

Cundari,

Vestberg,

Gustafsson

et al. 2023

Front. Syst. Neurosci.

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The cerebellum plays a major role in balance, motor control and sensorimotor integration, but also in cognition, language, and emotional regulation. Several neuropsychiatric disorders such as attention deficit-hyperactivity disorder (ADHD), autism spectrum disorder (ASD), as well as neurological diseases such as spinocerebellar ataxia type 3 (SCA3) are associated with differences in cerebellar function. Morphological abnormalities in different cerebellar subregions produce distinct behavioral symptoms related to the functional disruption of specific cerebro-cerebellar circuits. The specific contribution of the cerebellum to typical development may therefore involve the optimization of the structure and function of cerebro-cerebellar circuits underlying skill acquisition in multiple domains. Here, we review cerebellar structural and functional differences between healthy and patients with ADHD, ASD, and SCA3, and explore how disruption of cerebellar networks affects the neurocognitive functions in these conditions. We discuss how cerebellar computations contribute to performance on cognitive and motor tasks and how cerebellar signals are interfaced with signals from other brain regions during normal and dysfunctional behavior. We conclude that the cerebellum plays a role in many cognitive functions. Still, more clinical studies with the support of neuroimaging are needed to clarify the cerebellum’s role in normal and dysfunctional behavior and cognitive functioning.

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The Cerebellum and Implicit Sequencing: Evidence from Cerebellar Ataxia

et al. 2020

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Selective Procedural Memory Impairment but Preserved Declarative Memory in Spinocerebellar Ataxia Type 3

Cited by 6 publications

References 59 publications

Neurocognitive Changes in Spinocerebellar Ataxia Type 3: A Systematic Review with a Narrative Design

Neurocognitive Changes in Spinocerebellar Ataxia Type 3: A Systematic Review with a Narrative Design

Neurocognitive and cerebellar function in ADHD, autism and spinocerebellar ataxia

The Cerebellum and Implicit Sequencing: Evidence from Cerebellar Ataxia

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