Selective probiotic bacteria induce IL-10–producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell–specific intercellular adhesion molecule 3–grabbing nonintegrin

Smits, Hermelijn H.; Engering, Anneke; Kleij, Desirée van der; Jong, Esther C. de; Schipper, Kim; Capel, Toni M.M. van; Zaat, Bas A.J.; Yazdanbakhsh, Maria; Wierenga, Eddy A.; Kooyk, Yvette van

doi:10.1016/j.jaci.2005.03.036

Cited by 649 publications

(540 citation statements)

References 31 publications

(38 reference statements)

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“…37 Using a similar protocol, it can be shown that Lactobacillus rhamnosus GG (LGG) is able to induce T-cell hyporesponsiveness 38 and that Lactobacillus reuteri ASM20016 or Lactobacillus casei NIZO B255, but not Lactobacillus plantarum NIZO B253, are capable of priming DCs for the induction of regulatory T cells. 39 Similar fi ndings have been reported for Lactobacillus paracasei NCC2461 in mixed lymphocyte reactions using murine splenic CD4+ T cells and allogeneic splenocytes as accessory cells. 40 …”

Section: Introductionsupporting

confidence: 79%

“…This may be partly a question of the dose, which is often similar in animal studies and human trials despite the enormous difference in weight and intestinal size. Dose-response studies are urgently required, especially since there are indications that certain in vitro effects are seen only at low bacterial doses 39 and that high doses may produce opposite effects to those obtained at low doses. 47 The results of a human supplementation trial also suggest that lower doses can be more effective than higher doses.…”

Section: Final Comments and Thoughtsmentioning

confidence: 99%

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Probiotics and immunity

et al. 2009

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Probiotics are defi ned as live microorganisms that, when administered in adequate amounts, confer a health benefi t on the host, including the gastrointestinal tract. While this benefi cial effect was originally thought to stem from improvements in the intestinal microbial balance, there is now substantial evidence that probiotics can also provide benefi ts by modulating immune functions. In animal models, probiotic supplementation is able to provide protection from spontaneous and chemically induced colitis by downregulating infl ammatory cytokines or inducing regulatory mechanisms in a strain-specifi c manner. In animal models of allergen sensitization and murine models of asthma and allergic rhinitis, orally administered probiotics can straindependently decrease allergen-specifi c IgE production, in part by modulating systemic cytokine production. Certain probiotics have been shown to decrease airway hyperresponsiveness and infl ammation by inducing regulatory mechanisms. Promising results have been obtained with probiotics in the treatment of human infl ammatory diseases of the intestine and in the prevention and treatment of atopic eczema in neonates and infants. However, the fi ndings are too variable to allow fi rm conclusions as to the effectiveness of specifi c probiotics in these conditions.

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Section: Introductionsupporting

confidence: 79%

Section: Final Comments and Thoughtsmentioning

confidence: 99%

Probiotics and immunity

et al. 2009

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“…Christensen et al (93) showed that L. reuteri had the ability to inhibit induction of proinflammatory cytokines interleukin (IL)-12, IL-6, and TNF-α in murine dendritic cells (DCs). The priming of DCs by L. reuteri, which was initiated by the binding of C-type lectin DC-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN), resulted in an induction of regulatory T cells in vitro (94). A similar down-regulation of proinflammatory cytokines (e.g., TNF-α) by L. reuteri was also observed with macrophages, lipopolysaccharide-activated monocytes, and primary monocytederived macrophages from children with Crohn's disease (81,95).…”

Section: Reuteri Contributes To Tolerance In the Gutmentioning

confidence: 99%

Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm

Walter

Britton

Roos

2010

Proc. Natl. Acad. Sci. U.S.A.

274

279

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Vertebrates engage in symbiotic associations with vast and complex microbial communities that colonize their gastrointestinal tracts. Recent advances have provided mechanistic insight into the important contributions of the gut microbiome to vertebrate biology, but questions remain about the evolutionary processes that have shaped symbiotic interactions in the gut and the consequences that arise for both the microbes and the host. Here we discuss the biological principles that underlie microbial symbiosis in the vertebrate gut and the potential of the development of mutualism. We then review phylogenetic and experimental studies on the vertebrate symbiont Lactobacillus reuteri that have provided novel insight into the ecological and evolutionary strategy of a gut microbe and its relationship with the host. We argue that a mechanistic understanding of the microbial symbiosis in the vertebrate gut and its evolution will be important to determine how this relationship can go awry, and it may reveal possibilities by which the gut microbiome can be manipulated to support health.vertebrate symbiont | microbiota | mutualism

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“…In fact: (1) probiotics modulate and stabilize the composition of the microbiota and, therefore, may have immunomodulatory effects; (2) some probiotics are able to inhibit the inflammatory response of the intestinal immune system through inhibition of NF-B activation or in combination with an anti-apoptotic action on intestinal epithelial cells [31,32]; (3) some probiotics are able to increase the activity of Natural Killer (NK) cells [33,34], which are first line of defense as they can perform cytotoxic activities independent from prior sensitization to antigens; (4) some probiotics increase the secretion of mucus [22]; (5) some probiotics have a direct immunomodulatory action: after being captured in the Peyer's patches, they can induce the secretion of cytokines and the expression of co-stimulatory molecules by antigen presenting cells (APC) [35]; (6) some strains of lactobacilli induce dendritic cells (DC) maturation [36]. DC can, through their particular cytostructure, pass through the layer of epithelial cells and capture antigens directly from the lumen.…”

Section: Probiotics and The Immune Responsementioning

confidence: 99%

Probiotics and health: An evidence-based review

Aureli

Capurso

Castellazzi

et al. 2011

Pharmacological Research

229

131

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a b s t r a c tThe intestinal microbiota is an ecosystem formed by a variety of ecological niches, made of several bacterial species and a very large amount of strains. The microbiota is in close contact with the intestinal mucosa or epithelial interface which is, after the respiratory area, the largest surface of the body, occupying approximately 250-400 m 2 . The physiological activities of the microbiota are manifold and are just being unraveled. Based on the observations of the multiple roles played by the microbiota in health and disease, the notion of modifying it with appropriate formulations, i.e. probiotics, is being tested in several settings.This review summarizes the current knowledge on probiotics and discusses both limitations and acquired evidence to support their use in preventive and therapeutic medicine.

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Selective probiotic bacteria induce IL-10–producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell–specific intercellular adhesion molecule 3–grabbing nonintegrin

Cited by 649 publications

References 31 publications

Probiotics and immunity

Probiotics and immunity

Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm

Probiotics and health: An evidence-based review

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