Selective pressurized liquid extraction as a sample-preparation technique for persistent organic pollutants and contaminants of emerging concern

Subedi, Bikram; Aguilar, Lissette; Robinson, Eleanor M.; Hageman, Kimberly J.; Björklund, Erland; Sheesley, Rebecca J.; Usenko, Sascha

doi:10.1016/j.trac.2015.02.011

Cited by 65 publications

(14 citation statements)

References 75 publications

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“…PLE shows a great potential for the extraction of metabolites from vegetable matrices [ 11 , 12 , 13 ] due to the possibility of using a variety of polar and non-polar solvents under high pressure, which improves the efficiency of the extraction process [ 14 , 15 ]. PLE enables extraction in a lower extraction time and using a small amount of solvent [ 16 , 17 ], and was also used for the exhaustive extraction of analytes in one or more clean-up steps [ 18 ]. In this sense, the PLE is considered a promising process to obtain natural compounds [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative Activity of Neem Leaf Extracts Obtained by a Sequential Pressurized Liquid Extraction

et al. 2018

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Azadirachta indica A. Juss (neem) extracts have been used in pharmaceutical applications as antitumor agents, due to their terpenes and phenolic compounds. To obtain extracts from neem leaves with potential antiproliferative effect, a sequential process of pressurized liquid extraction was carried out in a fixed bed extractor at 25 °C and 100 bar, using hexane (SH), ethyl acetate (SEA), and ethanol (SE) as solvents. Extractions using only ethanol (EE) was also conducted to compare the characteristics of the fractionated extracts. The results obtained by liquid chromatography-electrospray ionization mass spectrometry suggested a higher concentration of terpenes in the SEA extract in comparison to SH, SE, and EE extracts. Therefore, antiproliferative activity showed that SEA extracts were the most efficient inhibitor to human tumor cells MCF-7, NCI-H460, HeLa, and HepG2. Hepatocellular cells were more resistant to SH, SEA, SE, and EE compared to breast, lung, hepatocellular, and cervical malignant cells. Neem fractioned extracts obtained in the present study seem to be more selective for malignant cells compared to the non-tumor cells.

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Section: Introductionmentioning

confidence: 99%

Antiproliferative Activity of Neem Leaf Extracts Obtained by a Sequential Pressurized Liquid Extraction

et al. 2018

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Section: Introductionmentioning

confidence: 99%

“…In recent years, a selective accelerated solvent extraction (SASE) was developed for use in simultaneously extracting target analytes and removing potential interfering matrix compounds by incorporating clean-up adsorbents. 24 The SASE technique has been used for the analysis of persistent organic pollutants and selected contaminants of emerging concern in solid environmental matrices. However, to date, selection of ASE adsorbents has not been developed for the physicochemical adsorptions that occur under typical ASE conditions, and there is no selective ASE report for the analysis of urea herbicides in food samples.…”

Section: Introductionmentioning

confidence: 99%

Residue investigation of some phenylureas and tebuthiuron herbicides in vegetables by ultra‐performance liquid chromatography coupled with integrated selective accelerated solvent extraction–clean up in situ

Ming

Jia

et al. 2018

J Sci Food Agric

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“…Selective PLE (SPLE) [4,5], Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) [3,[7][8][9], Matrix Solid-Phase Dispersion (MSPD) [3,4,7,10], Soxhlet [2,3,6,8], and dispersive Solid Phase Extraction (dSPE) [3,7,9,10].…”

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confidence: 99%

“…We used the ASE for this comparison because of similarities between EDGE and ASE instrumentation. SPLE has been described in detail in Subedi et al [5]. In brief, SPLE is conducted by packing the sample and a layer of selected sorbents into a stainless steel extraction cell.…”

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confidence: 99%

Comparison of Accelerated Solvent Extraction (ASE) and Energized Dispersive Guided Extraction (EDGE) for the analysis of pesticides in leaves

Kinross

Hageman

Doucette

et al. 2020

Journal of Chromatography A

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Various techniques have been evaluated for the extraction and cleanup of pesticides from environmental samples. In this work, a Selective Pressurized Liquid Extraction (SPLE) method for pesticides was developed using a Thermo Scientific Accelerated Solvent Extractor (ASE). This instrument was compared to the newly introduced (2017) extraction instrument, the Energized Dispersive Guided Extraction (EDGE), which combines Pressurized Liquid Extraction (PLE) and dispersive Solid Phase Extraction (dSPE). We first optimized the SPLE method using the ASE instrument for pesticide extraction from alfalfa leaves using layers of Florisil and graphitized carbon black (GCB) downstream of the leaf homogenate in the extraction cell (Layered ASE method). We then compared results obtained for alfalfa and citrus leaves with the Layered ASE method to those from a method in which the leaf homogenate and sorbents were mixed (Mixed ASE method) and to similar methods modified for use with EDGE (Layered EDGE and Mixed EDGE methods). The ASE and EDGE methods led to clear colorless extracts with low residual lipid weight. No significant differences in residual lipid masses were observed between the methods. The UV-Vis spectra showed that Florisil removed a significant quantity of the lightabsorbing chemicals but GCB was required to produce colorless extracts. Recoveries of spiked analytes into leaf homogenates were generally similar among methods, but in several cases, significantly higher recoveries were observed in ASE extracts. Nonetheless, no significant differences were observed among pesticide concentrations in field samples when calculated with the isotope dilution method in which labelled surrogates were added to samples before extraction. Extraction time using the ASE methods were ~45 minutes, which is ~4.5 times longer than the EDGE methods. The EDGE methods use ~10 mL more solvent than the ASE methods. Based on these results, the EDGE is an acceptable extraction instrument and, for most compounds, the EDGE has a similar extraction efficiency to the ASE.

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Selective pressurized liquid extraction as a sample-preparation technique for persistent organic pollutants and contaminants of emerging concern

Cited by 65 publications

References 75 publications

Antiproliferative Activity of Neem Leaf Extracts Obtained by a Sequential Pressurized Liquid Extraction

Antiproliferative Activity of Neem Leaf Extracts Obtained by a Sequential Pressurized Liquid Extraction

Residue investigation of some phenylureas and tebuthiuron herbicides in vegetables by ultra‐performance liquid chromatography coupled with integrated selective accelerated solvent extraction–clean up in situ

Comparison of Accelerated Solvent Extraction (ASE) and Energized Dispersive Guided Extraction (EDGE) for the analysis of pesticides in leaves

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