Selective presence of IgG2b inducing factor in synovial fluid of patients with rheumatoid arthritis

Ridderstad, Anna; Abedi‐Valugerdi, Manuchehr; Ström, Håkan; Möller, Erna

doi:10.1016/s1043-4666(05)80009-2

Cited by 4 publications

(6 citation statements)

References 22 publications

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“…The effect of IgG2bIF on human B cells is still unknown. IgG2bIF was found to be present in 77% of RA-SF and in 55% of non-RA-SF in this work, corresponding to previous work in which IgG2bIF was found in 83% of RA-SF and 41% of non-RA-SF samples [18]. Higher levels of IL-10 and IL-1b were found in IgG2bIF-positive SF samples than in IgG2bIF-negative ones.…”

Section: Discussionsupporting

confidence: 87%

“…We have previously shown that there is no correlation between the levels of IL-6 and IgG2bIF in SF [18]. This result is confirmed in the present work.…”

Section: Presence Of Igg2bif Correlates With High Levels Of Il-10 Andsupporting

confidence: 92%

“…We have previously found that IgG2bIF is present mainly in SF from patients with RA, compared to patients with other arthritides [18]. High levels of IL-10 in SF have also been correlated with RA [8].…”

Section: Introductionmentioning

confidence: 93%

See 2 more Smart Citations

Synovial Fluid Cytokines in Patients with Rheumatoid Arthritus or Other Arthritic Lesions

Lettesjö¹,

Nordström²,

Ström³

et al. 1998

Scand J Immunol

103

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Section: Discussionsupporting

confidence: 87%

“…We have previously shown that there is no correlation between the levels of IL-6 and IgG2bIF in SF [18]. This result is confirmed in the present work.…”

Section: Presence Of Igg2bif Correlates With High Levels Of Il-10 Andsupporting

confidence: 92%

See 1 more Smart Citation

Synovial Fluid Cytokines in Patients with Rheumatoid Arthritus or Other Arthritic Lesions

Lettesjö¹,

Nordström²,

Ström³

et al. 1998

Scand J Immunol

103

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“…Locally produced cytokines most probably influence the maturation of B cells and contribute to the maintenance of the chronic inflammation of the joint. In our experimental model, we have shown that the IgG2bIF, which is selectively present in SF from RA patients [36], has B cell activating properties and might therefore be an important cytokine for B cell differentiation in the joints of RA patients. The aim of this study is to elucidate whether IgG2bIF binds directly to highly purified LPS activated B lymphocytes, or if it activates accessory cells to produce a factor that triggers B cells to produce IgG2b antibodies.…”

Section: Introductionmentioning

confidence: 83%

IgG2b Inducing Factor from Rheumatoid Arthritis Synovial Fluid Activates Antibody Production in Highly Purified Mouse B Lymphocytes

Lettesjö

Möller

1997

Scand J Immunol

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Rheumatoid arthritis synovial fluid (RA‐SF) contains a factor that induces IgG2b antibody production in LPS‐stimulated murine B cells and therefore is called IgG2b inducing factor (IgG2bIF). When LPS, together with crude RA‐SF or semi‐purified IgG2bIF, was added to highly purified LPS‐stimulated B cells, the number of IgG2b‐producing cells was substantially enhanced. This shows that IgG2bIF acts directly on activated B cells, presumably by binding to a receptor expressed on LPS‐activated B cells. In vivo LPS‐activated B blasts were not able to respond to RA‐SF unless LPS was present in vitro, showing that LPS is needed to maintain cell viability and responsiveness to the IgG2bIF. To elucidate the mechanism for the IgG2bIF effect on highly purified B cells, the IgG2b response of LPS‐stimulated, Bruton's tyrosine kinase‐defective, xidB blasts was studied. Purified B blasts from the btk‐defective CBA/N mouse strain were sensitive to IgG2bIF. These findings show that IgG2bIF acts directly on B cells and activates cells through a btk‐independent pathway.

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“…They include IL-1, IL-6, IL-8, IL-10, IL-15, IgG2bIF, TNF-a and TGF-b. However, only IL-10 and IgG2bIF have been claimed to be selectively present in the RA lesion [41,42, see also the accompanying paper]. Both these cytokines are B-cell differentiation factors [25,28].…”

Section: Discussionmentioning

confidence: 99%

Autoantibody Patterns in Synovial Fluids from Patients with Rheumatoid Arthritis or Other Arthritic Lesions

Lettesjö¹,

Nordström²,

Ström³

et al. 1998

Scand J Immunol

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Selective presence of IgG2b inducing factor in synovial fluid of patients with rheumatoid arthritis

Cited by 4 publications

References 22 publications

Synovial Fluid Cytokines in Patients with Rheumatoid Arthritus or Other Arthritic Lesions

Synovial Fluid Cytokines in Patients with Rheumatoid Arthritus or Other Arthritic Lesions

IgG2b Inducing Factor from Rheumatoid Arthritis Synovial Fluid Activates Antibody Production in Highly Purified Mouse B Lymphocytes

Autoantibody Patterns in Synovial Fluids from Patients with Rheumatoid Arthritis or Other Arthritic Lesions

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