Selective Potentiation of Peripheral Chemoreflex Sensitivity in Obstructive Sleep Apnea

Narkiewicz, Krzysztof; Borne, Philippe J. H. van de; Pesek, Catherine A.; Dyken, Mark Eric; Montano, Nicola; Somers, Virend K.

doi:10.1161/01.cir.99.9.1183

Cited by 465 publications

(377 citation statements)

References 38 publications

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“…The present data do not indicate why housing had such an effect, but knowing that social interactions and play promote "optimal" central nervous system development in young rats (15,48), we propose that such interactions were higher in pups housed in triads than in pairs. The overall effects of housing on respiratory regulation reported here may be viewed as marginal, but it is noteworthy that, in humans, the HVR of patients with sleep-disordered breathing is 29% greater than in healthy subjects (41). Considering that the HVR attenuation resulting from triad housing in NMS rats is well within that range, the physiological benefits from this form of enrichment may be significant.…”

Section: Perspectivesmentioning

confidence: 76%

Influence of juvenile housing conditions on the ventilatory, thermoregulatory, and endocrine responses to hypoxia of adult male rats

Fournier

Joseph

Kinkead

2011

Journal of Applied Physiology

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Fournier S, Joseph V, Kinkead R. Influence of juvenile housing conditions on the ventilatory, thermoregulatory, and endocrine responses to hypoxia of adult male rats. J Appl Physiol 111: 516 -523, 2011. First published May 19, 2011 doi:10.1152/japplphysiol.00370.2011.-"Extreme" housing conditions, such as isolation (single housing) or crowding, are stressful for rats, and their deleterious impact on behavior is well documented. To determine whether more subtle variations in housing can affect animal physiology, the present study tested the hypothesis that the hypoxic ventilatory response (HVR) of adult male rats housed in pairs during the juvenile period (postnatal day 21 to adulthood) does not differ from that of animals housed in triads. Because neonatal stress augments the neuroendocrine responsiveness to stress and HVR, experiments were performed both on "control" (undisturbed) animals and rats subjected to neonatal maternal separation (NMS; 3 h/day, postnatal days 3-12). At adulthood, ventilatory activity was measured by whole body plethysmography under normoxic and hypoxic conditions (inspired fraction of O2 ϭ 0.12; 20 min). The ventilatory and body temperature responses to hypoxia of rats raised in triads were less than those of rats housed in pairs. For the HVR, however, the attenuation induced by triad housing was more important in NMS rats. Triad housing decreased "basal" plasma corticosterone, but increased estradiol and testosterone levels. Much like the HVR, housing-related decrease in corticosterone level was greater in NMS than control rats. We conclude that modest changes in housing conditions (pairs vs. triads) during the juvenile period can influence basic homeostatic functions, such as temperature, endocrine, and respiratory regulation. Housing conditions can influence (even eliminate) the manifestations of respiratory plasticity subsequent to deleterious neonatal treatments. Differences in neuroendocrine function likely contribute to these effects. control of breathing; maternal separation; environment; chemoreflex; temperature regulation; hormone IN RATS, HOUSING CONDITIONS from weaning until adulthood have a significant impact on animal development and health. Extreme housing conditions, such as social isolation (single housing) or crowding (ϳ3.0 dm 3 /rat), are stressful to the juvenile animal and promote the emergence of anxiety, depression, and hypertension, and augment stress responsiveness at adulthood (7,36,50). By contrast, enrichment of the animal's environment with group housing, various objects, and larger cages facilitates natural social behaviors and improves animal health by making them more resilient to stressful conditions (31). In most animal care facilities, however, "standard" housing conditions (postweaning) consist of placing multiple animals within the same cage. The actual housing conditions are rarely documented, but a brief survey of the literature reveals important variations between laboratories: some report housing rats four to five per cage (36), whereas others ...

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Section: Perspectivesmentioning

confidence: 76%

Influence of juvenile housing conditions on the ventilatory, thermoregulatory, and endocrine responses to hypoxia of adult male rats

Fournier

Joseph

Kinkead

2011

Journal of Applied Physiology

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“…Thus, the persistently lowered P a, J is likely to be the stimulus triggering and maintaining high efferent sympathetic outflow in chronic hypoxia via its action on the peripheral and central chemoreceptors (Gonzalez et al 1994;Marshall, 1994;Reis et al 1994;Sun & Reis, 1995). In fact, investigations conducted with patients suffering from obstructive sleep apnoea have shown increased blood pressure and sympathetic activation dependent on the reduction of P a, J (Narkiewicz et al 1999;Imadojemu et al 2002), thereby supporting a role for intermittent hypoxaemia in the pathogenesis of sympathetic overactivity. The present investigation suggests that a similar mechanism may also operate in healthy humans living at altitude.…”

Section: Figure 1 Blood Pressure and Vascular Conductancesmentioning

confidence: 98%

Chronic hypoxia increases blood pressure and noradrenaline spillover in healthy humans

Calbet¹

2003

J Physiology

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“…Acute application of CPAP (42). Although the effects of CPAP on autonomic and cardiovascular alterations remain controversial, evidence suggests that appropriate CPAP treatment for OSAS ameliorates sympathetic hyperactivity as well as tonic activation of peripheral chemoreceptors and hyperresponsiveness to hypoxia (43)(44)(45).…”

Section: Effect Of Cpap Treatment On the Brsi In Osas Patientsmentioning

confidence: 99%

Continuous Positive Airway Pressure Improves Daytime Baroreflex Sensitivity and Nitric Oxide Production in Patients with Moderate to Severe Obstructive Sleep Apnea Syndrome

et al. 2007

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Selective Potentiation of Peripheral Chemoreflex Sensitivity in Obstructive Sleep Apnea

Abstract: OSA is associated with a selective potentiation of autonomic, hemodynamic, and ventilatory responses to peripheral chemoreceptor activation by hypoxia.

Cited by 465 publications

References 38 publications

Influence of juvenile housing conditions on the ventilatory, thermoregulatory, and endocrine responses to hypoxia of adult male rats

Influence of juvenile housing conditions on the ventilatory, thermoregulatory, and endocrine responses to hypoxia of adult male rats

Chronic hypoxia increases blood pressure and noradrenaline spillover in healthy humans

Continuous Positive Airway Pressure Improves Daytime Baroreflex Sensitivity and Nitric Oxide Production in Patients with Moderate to Severe Obstructive Sleep Apnea Syndrome

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