Selective potentiation of opioid analgesia by nonsteroidal anti-inflammatory drugs

Zelcer, Shayna; Kolesnikov, Yuri; Kovalyshyn, Ivanka; Pasternak, David A.; Pasternak, Gavril W.

doi:10.1016/j.brainres.2005.01.070

Cited by 48 publications

(25 citation statements)

References 42 publications

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“…Aspirin and levetiracetam-aspirin combination produced high antinociceptive efficacy in diabetic mice in both tests compared to weak efficacy (tail-flick test), and no effect (von Frey test) in nondiabetic mice. The general lack of antinociception of individually applied drugs in non-diabetic mice is in line with previous studies which showed no effect of levetiracetam [6,7], ibuprofen [36], aspirin [37,38] and paracetamol [39] in healthy mice/rats in thermal/mechanical pain tests. Therefore, we could hypothesize that the determined antinociceptive effects of levetiracetam, analgesics and levetiracetam-analgesic combinations in diabetic mice are dependent on neuropathic changes caused by diabetes.…”

Section: Discussionsupporting

confidence: 88%

Levetiracetam synergises with common analgesics in producing antinociception in a mouse model of painful diabetic neuropathy

Micov

Tomić

Pecikoza

et al. 2015

Pharmacological Research

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Section: Discussionsupporting

confidence: 88%

Levetiracetam synergises with common analgesics in producing antinociception in a mouse model of painful diabetic neuropathy

Micov

Tomić

Pecikoza

et al. 2015

Pharmacological Research

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“…Nevertheless, Lokken et al (1908) and Hinz et al (2007a, b) have reported that both metamizol and paracetamol possess antiinflammatory activities. Furthermore, the findings of the present work seems to indicate that metamizol and paracetamol exert an antinociceptive action in the tail-flick test, an assay in which previous studies failed to detect analgesic activity for any of the NSAIDs (Kolesnikov et al 2003;Zelcer et al 2005).…”

Section: Discussionmentioning

confidence: 53%

Synergism between COX-3 inhibitors in two animal models of pain

et al. 2010

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These actions can be related to the differential selectivity of the drugs for inhibition of COX isoforms and also to the several additional antinociception mechanisms and pathways initiated by the analgesic drugs on pain transmission. Since the efficacy of the combination of metamizol with paracetamol has been demonstrated in the present study, this association could have a potential beneficial effect on the pharmacological treatment of clinical pain.

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“…Opioids have long been marketed as combination products, initially with acetaminophen and aspirin and then with NSAIDs such as ibuprofen. Clinicians appreciate the advantages of both classes of drugs together, and there is preclinical evidence suggesting the possibility of synergy between these agents (Kolesnikov et al, 2003b;Zelcer et al, 2005). Opiates also are used extensively with local anesthetics, particularly when administered epidurally or intradurally (Nordberg, 1984;Payne, 1987;Arner et al, 1988), an approach validated in animal models (Durant and Yaksh, 1986).…”

Section: Analgesiamentioning

confidence: 99%