“…Unlike the other four members of the NFAT family, which are regulated by calcium–calcineurin, NFAT5 is found in all cell types and is regulated by osmotic stress (Macian, ). DLG1 regulates Ag‐dependent cytoskeletal and signaling events by localizing to the junction between T cells and antigen‐presenting cells, also known as the immunological synapse (Crocetti, Silva, Humphries, Tibbs, & Miceli, ; Zanin‐Zhorov et al., ). Tumor necrosis factor receptor‐associated factor 3 (TRAF3) is an adaptor molecule that links upstream receptor signals to downstream gene activation in both adaptive immune cells and the innate immune system (Oganesyan et al., ; Yi, Lin, Stunz, & Bishop, ).…”