Selective nucleophilic substitution reactions on poly(epichlorohydrin) using aromatic and aliphatic thiol compounds

Synthesis of nitric oxide-releasing polyurethanes with S-nitrosothiol-containing hard and soft segments

“…7 Although polyurethanes are typically composed of both hydrophilic soft segments and hydrophobic hard segments, surface segregation phenomena and surface restructuring upon contact with water provides polyurethanes with the enhanced blood compatibility seen for completely hydrophilic materials. 7–10 In addition to improved haemocompatibility, the elastomeric and broad mechanical properties provided by the microphase separation of the hard and soft segments make polyurethanes attractive candidates for use in the design of implants. 7 Despite these advantages, protein and platelet adhesion to polyurethane surfaces remain problematic in the clinical implementation of devices that use this material.…”

Solubilization and polymer analogous reactions of polyepichlorohydrin in ionic liquids

“…On the basis of these solubilization results, we studied the polymer analogous reactions of polyepichlorohydrin using ionic liquids as the reaction media because it showed high solubility in [bmim][Cl] and formed a dispersion in [bmim][BF 4 ] and [bmim][PF 6 ]. Polyepichlorohydrin is often a starting polymer in polymer analogous reactions because the chloromethyl side group can be easily substituted by various nucleophilic compounds in organic solvents to produce polymer systems with important functionalities such as liquid crystallinity, barrier properties, and curing ability 13–17. Polyepichlorohydrin was reacted with thiolate anions to obtain polymers with thioether linkage groups.…”

Immobilization of antibodies on aldehyde-functionalized polymer/graphene films for the fabrication of a label-free electrochemical immunosensor

“…Moreover, chlorine atoms can be efficiently substituted by many nucleophilic reagents such as aliphatic carboxylates, sodium methoxide and series of substituted phenolates under mild conditions [19]. Thus, it has been used as a starting material for synthesizing novel functional polymers including well-defined DNA-mimicking brush polymers [20], self-assembled brush glycopolymers [21], and lipid-mimicking brush polymers [22].…”