Selective Nodal Irradiation for Head and Neck Cancer Using Intensity-Modulated Radiotherapy: Application of RTOG Consensus Guidelines in Routine Clinical Practice

Quantification of the effect of treatment duration on local‐regional failure after definitive concurrent chemotherapy and intensity‐modulated radiation therapy for squamous cell carcinoma of the head and neck

“…11,13,28 Estimates of the detrimental effect of treatment interruption during CCRT with IMRT for SCCHN on survival and local control vary between 1% to 5% per day. 11,13,15 The findings from our comparative analysis of cohorts 1 and 2 are consistent with the literature. In this experience, there were only 3 cases of locoregional progression in the group (cohort 2) for which steps were taken to minimize treatment interruption as opposed to 15 cases of locoregional progression in cohort 1.…”

“…CCRT duration was dichotomized based on the results of McCloskey et al 13 and Rades et al 11 Interruption of radiation therapy dichotomized as ≤56 days or ≥57 days was a significant predictor of locoregional progression in both of these studies. Additionally, Nangia et al 15 reported a similar outcome. Treatment duration for this analysis was therefore dichotomized into clinically relevant categories of ≤56 days or ≥57 days.…”

Prospective Assessment of Patterns of Failure After High-Precision Definitive (Chemo)Radiation in Head-and-Neck Squamous Cell Carcinoma

“…Most of the failures were truly in-field in the high-dose region, consistent with previously published data (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). In large series (Table 4) the predominant pattern of failure after CRT for HNSCC has been in-field within the GTV, with marginal failures ranging from 0% to 25%.…”

“…Consensus guidelines for target volume delineation in the node-negative neck (7) as well as node-positive neck and in the postoperative setting (8), have been adopted widely in routine clinical practice (21), but there continues to be widespread variation in the delineation of GTV at the primary site, even with multimodality imaging (28,29). There is poor correlation between the extent of gross disease at the primary y This lymph node was neither clinically palpable nor visible on response-assessment 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography, but it was reported as a small involved node on pathology of salvage surgery.…”

Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation

“…Recently, Nangia et al reported results of 83 head and neck cancers treated by IMRT method [30]. In their series, hypopharyngeal cancer was present in 13 and laryngeal cancer in 35 patients.…”