Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla

Nguyen, Van Thi Bao; Darbour, Nicole; Bayet, Christine; Doreau, Agnès; Raad, Imad; Phung, Binh Hoa; Dumontet, Charles; Pietro, Attilio Di; Dijoux‐Franca, Marie‐Geneviève; Guilet, David

doi:10.1016/j.fitote.2008.09.010

Cited by 32 publications

(15 citation statements)

References 23 publications

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“…been investigated [Cheung et al, 2005;Lee et al, 2005;Ong et al, 2008]. It was also reported that PD inhibits P-glycoproteinmediated anti-tumour drug efflux in multidrug resistant human leukemia cells [Nguyen et al, 2009]. In a proteomic study, PD was found to upregulate typical endoplasmic reticulum stress-related proteins/genes including glucose-regulated protein 78 and protein disulfide isomerase [Siu et al, 2008].…”

Section: Discussionmentioning

confidence: 99%

Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo

Chan

Koon

Liu

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo

Chan

Koon

Liu

et al. 2011

Journal of Ethnopharmacology

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“…Dioscin (Cai et al, 2002;Zhang et al, 2006;Wang et al, 2007a;Yun et al, 2007;Nguyen et al, 2009), one of the components of RPS, is a preclinical drug showing potent antiproliferative activities against most cell lines from leukemia and solid tumors. In cell culture experiments with HeLa cervix carcinoma cells, it could dose-and time-dependently induce apoptosis via the mitochondrial pathway.…”

Section: Introductionmentioning

confidence: 99%

Paridis saponins inhibiting carcinoma growth and metastasis In vitro and in vivo

et al. 2011

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Paris polyphylla Smith var. yunnanensis extracts, Rhizoma Paridis saponins (RPS) have been found to show strong antitumor activity. However, few studies have yet investigated pulmonary metastasis treatment with this herb. To detail the effective components in RPS and discuss the preliminary mechanism of antitumor effects in vivo and in vitro, a mixture isolated from RPS was investigated. The main constituents were identified as polyphyllin D, formosanin C, dioscin, Paris H, Paris VII and pennogennin 3-O-α-L-rhamnopyranosyl (1→4)-[β-L-rhamnopyranosyl (1→2)]-β-D-glucopyranoside. In our experiments, LA795 cells were exposed to the mixed compounds. Migration inhibition was evaluated by wound healing assay and migration assay in non-cytotoxic dose which was determined by MTT assay. The results demonstrated that the constituent in varying degrees inhibited the migration of the tumor cells in vitro. The mixture also showed antitumor effects on carcinoma in vivo. In conclusion, the mixture is a potent anticancer agent that elicits programmed cell death and inhibits the migration in murine lung adenocarcinoma, both in vitro and in vivo.

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“…4)]Glc-pennogenine exhibited the highest ability to modulate P-gp activity (108 and 77% inhibition at 20 and 10 mM, respectively), compared with cyclosporin A. The value of the gracillin and polyphyllin D were about 48 and 32%, 61 and 46% inhibition at 20 and 10 mM, respectively 127 . Conclusively, it is important to add that, substituents of sterides that mainly exist at the C 3 position (38)(39)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53), at the C 16 -C 17 position (38, 41, 42 and 43) and at the C 17 position (39,40), could be important for their P-gp inhibitory effects 128 .…”

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confidence: 97%

Advances in plant-based inhibitors of P-glycoprotein

Zhou

James

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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Multidrug resistance (MDR) has emerged as the main problem in anti-cancer therapy. Although MDR involves complex factors and processes, the main pivot is the expression of multidrug efflux pumps. P-glycoprotein (P-gp) belongs to the family of adenosine triphosphate (ATP)-binding cassette (ABC) transporters. It functions in cellular detoxification, pumping a wide range of xenobiotic compounds out of the cell. An attractive therapeutic strategy for overcoming MDR is to inhibit the transport function of P-gp and thus, increase intracellular concentration of drugs. Recently, various types of P-gp inhibitors have been found and used in experiments. However, none of them has passed clinical trials due to their high side-effects. Hence, the search for alternatives, such as plant-based P-gp inhibitors have gained attention recently. Therefore, we give an overview of the source, function, structure and mechanism of plant-based P-gp inhibitors and give more attention to cancer-related studies. These products could be the future potential drug candidates for further research as P-gp inhibitors.

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Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla

Cited by 32 publications

References 23 publications

Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo

Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo

Paridis saponins inhibiting carcinoma growth and metastasis In vitro and in vivo

Advances in plant-based inhibitors of P-glycoprotein

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