Selective laser sintering scaffold with hierarchical architecture and gradient composition for osteochondral repair in rabbits

Du, Yingying; Liu, Haoming; Yang, Qin; Wang, Shuai; Wang, Jianglin; Ma, Jun; Noh, Insup; Mikos, Antonios G.; Zhang, Shengmin

doi:10.1016/j.biomaterials.2017.05.021

Cited by 260 publications

(213 citation statements)

References 54 publications

(58 reference statements)

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“…When the pore sizes were small, the permeation rate of buffer solution into the scaffolds was slow, leading the low DRs. These results indicated that the catechol modification could effectively adjust the degradation of the scaffolds to be satisfied with the bone or cartilage regeneration …”

Section: Results and Disscussionmentioning

confidence: 82%

Fabrication of polydopamine nanoparticles knotted alginate scaffolds and their properties

Jiali

Shi

Dong

et al. 2018

J Biomedical Materials Res

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Polydopamine (PDA) can greatly affect polymer's properties, due to the chemical and physical interactions between the polymers and PDA. In this study, PDA was demonstrated to adjust the pore structures and increase the mechanical properties of alginate hydrogel‐based cartilage tissue scaffolds. Dopamine modified alginate (Alg‐DA) was firstly synthesized by modification of Alg with DA. Alg‐DA interacted with preprepared PDA nanoparticles and further crosslinked with calcium ions (Ca2+) to form the hydrogel scaffold (Alg‐DA/PDA). The Alg‐DA/PDA scaffold combined multiple advantageous features, including continuous pore structure, high level of porosity, well mechanical properties, good biocompatibility and appropriate cycle life of degradation. Moreover, it could provide an optimized forming environment for hydroxyapatite (HAp) by mineralization process, thus accelerating cartilage repair. The improved performances were mainly ascribed to physical enhancement of the PDA nanoparticles and crosslinking points among the polymers and catechol groups in DA. These findings might offer a guideline for fabricating robust biocompatible cartilage tissue scaffold. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3255–3266, 2018.

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Section: Results and Disscussionmentioning

confidence: 82%

Fabrication of polydopamine nanoparticles knotted alginate scaffolds and their properties

Jiali

Shi

Dong

et al. 2018

J Biomedical Materials Res

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“…Using selective laser sintering, several bone compatible scaffolds have been printed (Du et al, ). With its unprecedented resolution and high precision, laser‐assisted bioprinting has been applied to in situ printing.…”

Section: Bioprinting Technologiesmentioning

confidence: 99%

Advances in three‐dimensional bioprinting of bone: Progress and challenges

Midha

Dalela

Sybil

et al. 2019

J Tissue Eng Regen Med

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Several attempts have been made to engineer a viable three‐dimensional (3D) bone tissue equivalent using conventional tissue engineering strategies, but with limited clinical success. Using 3D bioprinting technology, scientists have developed functional prototypes of clinically relevant and mechanically robust bone with a functional bone marrow. Although the field is in its infancy, it has shown immense potential in the field of bone tissue engineering by re‐establishing the 3D dynamic micro‐environment of the native bone. Inspite of their in vitro success, maintaining the viability and differentiation potential of such cell‐laden constructs overtime, and their subsequent preclinical testing in terms of stability, mechanical loading, immune responses, and osseointegrative potential still needs to be explored. Progress is slow due to several challenges such as but not limited to the choice of ink used for cell encapsulation, optimal cell source, bioprinting method suitable for replicating the heterogeneous tissues and organs, and so on. Here, we summarize the recent advancements in bioprinting of bone, their limitations, challenges, and strategies for future improvisations. The generated knowledge will provide deep insights on our current understanding of the cellular interactions with the hydrogel matrices and help to unravel new methodologies for facilitating precisely regulated stem cell behaviour.

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“…In this study, biodegradation behavior of the Alg-DA/QCHA gradient scaffolds was detected in a simulated body fluid (SBF) for five weeks, as shown in Figure 4. 22,29 In vitro biomineralization behavior of Alg-DA/QCHA gradient scaffolds Natural bone is an inorganic-organic complex composed of HA and macromolecular collagen fibers. The bottom layer with high QCHA composition displayed a quicker degradation, compared to the other layers with lower QCHA compositions.…”

Section: Synthesis and Characterization Of Qchamentioning

confidence: 99%

Preparation and properties of dopamine‐modified alginate/chitosan–hydroxyapatite scaffolds with gradient structure for bone tissue engineering

Shi

Jiali

Zhang

et al. 2019

J Biomedical Materials Res

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Three‐dimensional (3D) homogenous scaffolds composed of natural biopolymers have been reported as superior candidates for bone tissue engineering. There are still remaining challenges in fabricating the functional scaffolds with gradient structures to similar with natural bone tissues, as well as high mechanical properties and excellent affinity to surround tissues. Herein, inspired by the natural bone structure, a gradient‐structural scaffold composed of functional biopolymers was designed to provide an optimized 3D environment for promoting cell growth. To increase the interactions among the scaffolds, dopamine (DA) was employed to modify alginate (Alg) and needle‐like nano‐hydroxyapatite (HA) was prepared with quaternized chitosan as template. The obtained dopamine‐modified alginate (Alg‐DA) and quaternized chitosan‐templated hydroxyapatite (QCHA) were then used to fabricate the porous gradient scaffold by “iterative layering” freeze‐drying technique with further crosslinking by calcium ions (Ca2+). The as‐prepared Alg‐DA/QCHA gradient scaffolds were possessed seamlessly integrated layer structures and high levels of porosity at around 77.5%. Moreover, the scaffolds showed higher compression modules (1.7 MPa) than many other biopolyermic scaffolds. The gradient scaffolds showed appropriate degradation rate to satisfy with the time of the bone regeneration. Both human chondrocytes and fibroblasts could adhesive and growth well on the scaffolds in vitro. Furthermore, an excellent osteogenetic activity of the gradient scaffold can effectively promote the regeneration of the bone tissue and accelerate the repair of the bone defects in vivo, compared with that of the scaffold with the homogenous structure. The novel multilayered scaffold with gradient structure provided an interesting option for bone tissue engineering. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1615–1627, 2019.

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Selective laser sintering scaffold with hierarchical architecture and gradient composition for osteochondral repair in rabbits

Cited by 260 publications

References 54 publications

Fabrication of polydopamine nanoparticles knotted alginate scaffolds and their properties

Fabrication of polydopamine nanoparticles knotted alginate scaffolds and their properties

Advances in three‐dimensional bioprinting of bone: Progress and challenges

Preparation and properties of dopamine‐modified alginate/chitosan–hydroxyapatite scaffolds with gradient structure for bone tissue engineering

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