Selective laser melted titanium implants play a positive role in early osseointegration in type 2 diabetes mellitus rats

Abstract

Success of dental implant is associated with the surface modification. To evaluate whether the selective laser melting-superfinished titanium (Ti6Al4V) implants have a better early osseointegration in type 2 diabetes mellitus rats compare to pure titanium implants and acid-etched treated (SLA) implants, we designed a screw-shaped implant which was batch-fabricated by selective laser melting (SLM). Then the implants were randomly inserted in tibias of rats with type 2 diabetes mellitus (T2DM). After surgical operation, the SLM group showed the best bone formation around the implants with the highest bone-implant contact rate among the three groups. Removal torque tests and histomorphological analyses all revealed a stronger connection between the bone because its good surface characteristics and mechanical properties. SLM implant may be a novel implant for T2DM patients.

Silk Fibroin/Hydroxyapatite Coating Improved Osseointegration of Porous Titanium Implants under Diabetic Conditions via Activation of the PI3K/Akt Signaling Pathway

“…Porous TIs precisely fabricated by the EBM manufacturing technique have been extensively used in orthopedic applications . However, DM, as a kind of metabolic disorder, has been reported to decrease bone mineral content and retard the process of implant fixation, leading to the implant failure . Previous reports have indicated that an overall reduction in bone turnover rather than excessive bone resorption contributed to DM-induced bone healing impair. , The abnormal osteoblast structure and biological functions at the bone–implant interface play a critical role in the above process .…”

Strontium‐incorporated titanium implant surfaces treated by hydrothermal treatment enhance rapid osseointegration in diabetes: A preclinical vivo experimental study

“…Appropriate surface micro-scale structures have benefits on implant osseointegration (Albrektsson & Wennerberg, 2004;Wennerberg et al, 1998) and nano-scale features can promote interaction among implant surfaces, proteins, and cells (Mendonca et al, 2008). Selective laser-melted titanium implants can increase surface roughness to play a positive role in early osseointegration in type 2 diabetes mellitus rats (Duan et al, 2020).…”

“…Appropriate surface micro‐scale structures have benefits on implant osseointegration (Albrektsson & Wennerberg, 2004; Wennerberg et al, 1998) and nano‐scale features can promote interaction among implant surfaces, proteins, and cells (Mendonca et al, 2008). Selective laser‐melted titanium implants can increase surface roughness to play a positive role in early osseointegration in type 2 diabetes mellitus rats (Duan et al, 2020). Besides, more studies about surface modification in the diabetic model are focus on bioactive molecules, such as adiponectin (Hu et al, 2017), 1α,25‐dihydroxyvitamin D3 (Xiong et al, 2017), PPAR‐γ (Lee et al, 2017), and microRNAs(miRNAs) (Liu et al, 2017).…”

Berberine promotes peri‐implant osteogenesis in diabetic rats by ROS‐mediated IRS‐1 pathway

“…Poor peri‐implant osteogenesis is a frequent type of implant failure in diabetic patients. Excepted from local treatment, such as, surface modification of implants, systemic improvement of DM‐OS is a current hotspot in research aiming to advance implant osseointegration in DM patients 22–24 . The effect of BBR in reducing glycemia and facilitating osteogenesis has been gradually and independently revealed.…”