Selective knockdown of GABAA‐α2 subunit in the dorsal dentate gyrus in adulthood induces anxiety, learning and memory deficits and impairs synaptic plasticity
Kuldeep Tripathi,
Somoday Hazra,
Joyeeta Dutta Hazra
et al.
Abstract:Animal studies and clinical trials suggest that maintenance of gamma‐aminobutyric acid (GABA)‐ergic activity may be crucial in coping with stressful conditions, anxiety and mood disorders. Drugs highly efficient in promoting anxiolysis were shown to activate this system, particularly via the α2‐subunit of type A receptors (GABAA α2). Given the high expression of GABAA α2 in the dentate gyrus (DG) sub‐field of the hippocampus, we sought to examine whether manipulation of the α2 subunit in this area will evoke c… Show more
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