Selective Killing of Pathogenic Bacteria by Antimicrobial Silver Nanoparticle—Cell Wall Binding Domain Conjugates

Kim, Domyoung; Kwon, Seok Joo; Wu, Xia; Sauve, Jessica; Lee, In-Seon; Nam, Jahyun; Kim, Jungbae; Dordick, Jonathan S.

doi:10.1021/acsami.8b00181

Cited by 53 publications

(47 citation statements)

References 46 publications

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“…The formation of AgNPs was then confirmed by UV–Vis spectroscopy (Figure 1(a)) and TEM analysis (inset of Figure 1(b)). UV–Vis spectroscopy is a widely used technique to assess the formation and obtain in first instance a structural characterization of silver nanoparticles in colloidal solution 31 . The absorption spectrum of AgNPs shown in Figure 1(a) is dominated by the typical surface plasmon of the silver nanoparticles which gives a characteristic band in the visible region.…”

Section: Resultsmentioning

confidence: 99%

Tuning the antimicrobial activity of collagen biomaterials through a liposomal approach

Municoy

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et al. 2020

J of Applied Polymer Sci

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The development of advanced biocidal agents stands as a global challenge, focused on the increasing demand of new biomaterials with local and gradual release of antimicrobial agents. This is the first time that three well‐known materials are strategically combined to develop a novel biomaterial with long‐term bactericidal activity that avoids burst release and toxic effects, by the incorporation of silver nanoparticles in liposomes and the subsequent incorporation of these assemblies in collagen hydrogels. These systems show improved mechanical properties and prolonged inhibitory effect on the growth of Gram‐positive (Staphylococcus aureus) and Gram‐negative (Pseudomonas aeruginosa) bacteria, while remaining highly biocompatible for epithelial cells. In fact, the hybrid biocomposite prevents bacterial colonization for at least 72 h, allowing at the same time eukaryotic cell proliferation. As a result, this new bactericidal biomaterial provides a new alternative to improve current treatments of bacterial infections with many implications in significant applications, such as wound therapy and tissue regeneration.

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Section: Resultsmentioning

confidence: 99%

Tuning the antimicrobial activity of collagen biomaterials through a liposomal approach

Municoy

Antezana

Pérez

et al. 2020

J of Applied Polymer Sci

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“…[8][9][10] Given their binding specicity, endolysins and in particular the CBDs constitute highly attractive scaffolds for antibacterial protein engineering. 11,12 Listeria phage A500 encodes the endolysin Ply500, which comprises L-alanoyl-D-glutamate endopeptidase activity against Listeria spp. serovars 4, 5, and 6.…”

Section: Introductionmentioning

confidence: 99%

Structural basis for recognition of bacterial cell wall teichoic acid by pseudo-symmetric SH3b-like repeats of a viral peptidoglycan hydrolase

et al. 2021

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“…Besides AuNPs, other nanomaterials conjugated with AMPs such as AgNPs [ 259–267 ] and magnetic nanoparticles [ 268,269 ] were also reported on improving the antimicrobial activity. For instance, Yuan et al.…”

Section: Other Applications Of Peptide–gold Hybrid Nanomaterialsmentioning

confidence: 99%

Rational Design of Functional Peptide–Gold Hybrid Nanomaterials for Molecular Interactions

et al. 2020

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Gold nanoparticles (AuNPs) have been extensively used for decades in biosensing‐related development due to outstanding optical properties. Peptides, as newly realized functional biomolecules, are promising candidates of replacing antibodies, receptors, and substrates for specific molecular interactions. Both peptides and AuNPs are robust and easily synthesized at relatively low cost. Hence, peptide–AuNP‐based bio‐nano‐technological approaches have drawn increasing interest, especially in the field of molecular targeting, cell imaging, drug delivery, and therapy. Many excellent works in these areas have been reported: demonstrating novel ideas, exploring new targets, and facilitating advanced diagnostic and therapeutic technologies. Importantly, some of them also have been employed to address real practical problems, especially in remote and less privileged areas. This contribution focuses on the application of peptide–gold hybrid nanomaterials for various molecular interactions, especially in biosensing/diagnostics and cell targeting/imaging, as well as for the development of highly active antimicrobial/antifouling coating strategies. Rationally designed peptide–gold nanomaterials with functional properties are discussed along with future challenges and opportunities.

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Selective Killing of Pathogenic Bacteria by Antimicrobial Silver Nanoparticle—Cell Wall Binding Domain Conjugates

Cited by 53 publications

References 46 publications

Tuning the antimicrobial activity of collagen biomaterials through a liposomal approach

Tuning the antimicrobial activity of collagen biomaterials through a liposomal approach

Structural basis for recognition of bacterial cell wall teichoic acid by pseudo-symmetric SH3b-like repeats of a viral peptidoglycan hydrolase

Rational Design of Functional Peptide–Gold Hybrid Nanomaterials for Molecular Interactions

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