2018
DOI: 10.1111/jon.12511
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Selective Inversion Recovery Quantitative Magnetization Transfer Brain MRI at 7T: Clinical and Postmortem Validation in Multiple Sclerosis

Abstract: SIR-qMT at 7T provides sensitive, quantitative measures of myelin integrity for clinical and research applications.

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Cited by 21 publications
(24 citation statements)
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“…Recent developments in quantitative MT (qMT) methods attempt to reduce these confounding influences by providing more tissue-specific indices. 52 Another promising technique is inhomogeneous magnetization transfer (ihMT) 53 which appears to be specific to CNS lipids, which enrich myelin. Myelin water imaging (MWI) is another MRI technique designed to detect myelin alterations.…”
Section: Advances In Understanding Disease Mechanismsmentioning
confidence: 99%
“…Recent developments in quantitative MT (qMT) methods attempt to reduce these confounding influences by providing more tissue-specific indices. 52 Another promising technique is inhomogeneous magnetization transfer (ihMT) 53 which appears to be specific to CNS lipids, which enrich myelin. Myelin water imaging (MWI) is another MRI technique designed to detect myelin alterations.…”
Section: Advances In Understanding Disease Mechanismsmentioning
confidence: 99%
“…We propose the first in vivo clinical translation of our optimized and histologically validated 20 SIR-qMT protocol and demonstrate (1) the clinical feasibility of SIR-qMT at 3 T and (2) the ability of SIR-qMT-derived metrics to predict radiological and clinical disease severity. We recognize that additional gains in scan efficiency may be required prior to widespread clinical adoption of the SIR-qMT technique described here.…”
Section: Discussionmentioning
confidence: 99%
“…maps of the main magnetic field, the transmit radio frequency field, and the spin-lattice relaxation time), resulting in a complicated data analysis pipeline. To alleviate these issues, the selective inversion recovery (SIR) qMT 13,1821 technique was developed. SIR-qMT is based on a simple two-pool model of inversion recovery data that does not require additional measurements.…”
Section: Introductionmentioning
confidence: 99%
“…The MT effect is a major confound in all CEST imaging studies if not properly modeled; however, it is also a well‐understood biophysical process. The literature quantifying the MT effect is vast, with many qMT studies in healthy and pathological tissues in the human body; thus, it has a well‐defined parameter range. However, most previous studies of in vivo CEST effects have either ignored the MT effect (eg, using the MTR asym ), or utilized an alternative fitting model, such as AREX, to simultaneously estimate MT and CEST effects.…”
Section: Discussionmentioning
confidence: 99%
“…However, the influence of the MT effect on these analyses has not been systematically explored. While several studies have investigated the MT effect in CEST imaging, most often the MT effect is removed as a confound, despite it having radiological significance in its own right . Therefore, eliminating this contrast mechanism in favour of CEST may also eliminate valuable information about the tissue under investigation.…”
Section: Introductionmentioning
confidence: 99%