Selective Insect Antifeedant and Toxic Action of Ryanoid Diterpenes

González-Coloma⊥, Azucena; Gutiérrez, Carmen; Hübner, Harald; Achenbach, Hans; Terrero, David; Fraga, Braulio M.

doi:10.1021/jf990359a

Cited by 47 publications

(37 citation statements)

References 23 publications

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“…The natural botanical insecticide 'Ryania', based on ryanodine, is effective against the fruit moth, coddling moth and corn earworm, European corn borer, and citrus thrips, but it is ineffective against the cabbage maggot, cauliflower worms or the boll weevil. Ryanodol, the hydrolysis product of ryanodine is also a botanical insecticide (Gonzalez-Coloma et al 1999).…”

Section: Ryanodine and Ryanoids-insecticides Based On A Natural Productmentioning

confidence: 99%

Insect ryanodine receptors: molecular targets for novel pest control chemicals

2008

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Ryanodine receptors (RyRs) are a distinct class of ligand-gated calcium channels controlling the release of calcium from intracellular stores. They are located on the sarcoplasmic reticulum of muscle and the endoplasmic reticulum of neurons and many other cell types. Ryanodine, a plant alkaloid and an important ligand used to characterize and purify the receptor, has served as a natural botanical insecticide, but attempts to generate synthetic commercial analogues of ryanodine have proved unsuccessful. Recently two classes of synthetic chemicals have emerged resulting in commercial insecticides that target insect RyRs. The phthalic acid diamide class has yielded flubendiamide, the first synthetic ryanodine receptor insecticide to be commercialized. Shortly after the discovery of the phthalic diamides, the anthranilic diamides were discovered. This class has produced the insecticides Rynaxypyr and Cyazypyr. Here we review the structure and functions of insect RyRs and address the modes of action of phthalic acid diamides and anthranilic diamides on insect ryanodine receptors. Particularly intersting is the inherent selectivity both chemical classes exhibit for insect RyRs over their mammalian counterparts. The future prospects for RyRs as a commercially-validated target site for insect control chemicals are also considered.

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Section: Ryanodine and Ryanoids-insecticides Based On A Natural Productmentioning

confidence: 99%

Insect ryanodine receptors: molecular targets for novel pest control chemicals

2008

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“…Feeding or settling inhibition (%FI or %SI) was calculated as %FI = [1À(T/C) Â 100], where T and C are the consumption of treated and control leaf disks, respectively, or %SI = [1À(%T 7 %C)], where %C and %T are percent aphids settled on control and treated leaf disks, respectively (Gutierrez et al, 1997;Reina et al, 2001). Ryanodine and polygodial were included as positive controls for S. littoralis and the aphids, respectively (González-Coloma et al, 1999;Moreno-Osorio et al, 2008).…”

Section: Choice Feeding Assaysmentioning

confidence: 99%

Bioactive triterpene derivatives from latex of two Euphorbia species

et al. 2008

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“…The comparative antifeedant effects of several non-alkaloidal and alkaloidal ryanoids supported the hypothesis of a ryanodol-specific mode of action in insects. 432,434 The insect-selective insecticidal and antifeedant effects of ryanodanes hold a promising future for their use as biopesticides. However their availability is a problem which would need to be addressed prior to potential exploitation.…”

Section: Diterpenesmentioning

confidence: 99%