“…However, other variants previously reported to be linked to trastuzumab-related decline in LVEF failed to replicate between these studies. In an effort to develop cardioprotective peptides ( Zerihun and Qvit, 2023 ), used computational methods to develop peptides that inhibit mitochondrial fission 1 (Fis1)/mitochondrial dynamics 51 kDa (Mid51) protein-protein interactions to reduce the cellular damage that can lead to cardiotoxicity. They identified two peptides, CVP-241 and CVP-242, and characterized their binding dynamic both in silico and in vitro .…”