Selective inhibition of MAO-A activity results in an antidepressant-like action of 2-benzoyl 4-iodoselenophene in mice

Green Approach for the Synthesis of Chalcogenyl‐ 2,3‐dihydrobenzofuran Derivatives Through Allyl‐phenols/ Naphthols and Their Potential as MAO‐B Inhibitors

“…By using mouse brain tissue, the obtained compounds (7ah, 7k-q, 8a-e, and 9a) were tested at concentrations of 20 and 200 μM for their effects on MAO-B activity, an enzyme responsible for catalyzing the oxidative deamination reaction of biogenic amines, such as dopamine. [29] The results demonstrated that compounds 7d [F (17,36) Currently the available MAO inhibitors have many adverse effects, resulting in therapeutic failures due to poor adherence. [30] Therefore, the discovery of new molecules with potential inhibitory activities on MAO-B is of great relevance to the search for more effective alternatives for the treatment of neurodegenerative diseases.…”

“…Velasquez et al demonstrated that (4-iodo-5-phenylselenophen-2-yl)(phenyl)methanone 1, a heterocyclic organoselenium compound containing a five-membered ring, inhibits selective cerebral MAO-A activity after intragastric administration in mice. [17] In another study, Sampaio et al showed that 3phenyl-4-(phenylseleno)isoquinoline 2 inhibited cerebral MAO-B activity ex vivo, with no effect on MAO-A (Figure 1). [18] In parallel, the 2,3-dihydrobenzofuran (2,3-DHB) scaffold is closely related to several biological activities, especially in the antioxidant field.…”

“…Velasquez et al . demonstrated that (4‐iodo‐5‐phenylselenophen‐2‐yl)(phenyl)methanone 1 , a heterocyclic organoselenium compound containing a five‐membered ring, inhibits selective cerebral MAO‐A activity after intragastric administration in mice [17] . In another study, Sampaio et al .…”

Biological activities of peptides obtained by pepsin hydrolysis of fishery products

“…Among the synthesized peptides, Val-Val-Phe-Glu-Val-Phe-Trp showed the highest monoamine oxidase A inhibitory activity (IC50 = 0.405 mM) [147]. Selective monoamine oxidase A inhibition increases the level of serotonin in the central nervous system and thus reduces symptoms of clinical depression [148]; in this sense, the hairtail monoamine oxidase A inhibitory peptides obtained can be used as functional ingredients for monoamine oxidase A inhibition or potential alternatives for antidepressant [148].…”

Recent Advances in the Synthesis of Selenophenes and Their Derivatives

“…In this context, selenophenes and their derivatives have been widely studied due to their intrinsic biological activity [22], such as antidepressant [23][24][25][26][27][28], antioxidant [29][30][31][32][33][34][35], anticonvulsant [36,37], antibacterial [38], antitumor [39][40][41][42][43][44][45][46][47], antinociceptive [48], hepatoprotective [49,50] and antiapoptotic agents [51]. Besides, they have also played an important role in the materials science field, being used to build organic light emitting diodes (OLEDs) [52][53][54][55][56][57][58], organic field effect transistors (OFETs) [59][60][61][62][63][64][65][66][67][68]…”