Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation

Ramsey, Haley E.; Stengel, Kristy R.; Pino, James C.; Johnston, Gretchen; Childress, Merrida; Gorska, Agnieszka E.; Arrate, Pia; Fuller, Londa; Villaume, Matthew T.; Fischer, Melissa A.; Ferrell, P. Brent; Roe, Caroline E.; Zou, Jing; Lubbock, Alexander L R; Stubbs, Matthew C.; Zinkel, Sandra S.; Irish, Jonathan M.; López, Carlos F.; Hiebert, Scott W.; Savona, Michael R.

doi:10.1007/s11523-021-00830-5

Cited by 2 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Machine learning offers an effective tool for synthesizing and analyzing the amassing omics data to extract prominent features that can be used to develop mechanistic models for hypothesis generation. 49 , 64 As a first step, we look forward to the harmonization of our dataset with other recently published proteomic studies in AML 18 , 23 , 36 , 37 , 39 , 40 to improve prognostication, and better understand the biology of drug response in AML patients.…”

Section: Discussionmentioning

confidence: 99%

“… 24 , 25 , 26 , 27 This motivated the National Cancer Institute (NCI) to create the Clinical Proteomic Tumor Analysis Consortium (CPTAC), in which patient-derived samples were assayed using state-of-the-art mass spectrometry (MS) pipelines to produce proteomic and phosphoproteomic measurements of hundreds of tumors in breast, ovary, kidney, head and neck, endometrium, brain, and other tissues. 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 Efforts to study the impact of the proteomic signatures on drug response have been previously evaluated in AML cell lines 24 , 36 , 37 and in primary AML patient samples. 18 , 36 , 38 , 39 , 40 In each study, these proteomic measurements demonstrated patterns that were not evident at the genomic or transcriptomic level.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mapping the proteogenomic landscape enables prediction of drug response in acute myeloid leukemia

Pino,

Posso,

Joshi

et al. 2024

Cell Reports Medicine

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mapping the proteogenomic landscape enables prediction of drug response in acute myeloid leukemia

Pino,

Posso,

Joshi

et al. 2024

Cell Reports Medicine

Self Cite

View full text Add to dashboard Cite

A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder

Sarohan¹,

Kızıl

İnkaya

et al. 2021

Cellular Signalling

View full text Add to dashboard Cite

The SARS-CoV-2 virus has caused a worldwide COVID-19 pandemic. In less than a year and a half, more than 200 million people have been infected and more than four million have died. Despite some improvement in the treatment strategies, no definitive treatment protocol has been developed. The pathogenesis of the disease has not been clearly elucidated yet. A clear understanding of its pathogenesis will help develop effective vaccines and drugs. The immunopathogenesis of COVID-19 is characteristic with acute respiratory distress syndrome and multiorgan involvement with impaired Type I interferon response and hyperinflammation. The destructive systemic effects of COVID-19 cannot be explained simply by the viral tropism through the ACE2 and TMPRSS2 receptors. In addition, the recently identified mutations cannot fully explain the defect in all cases of Type I interferon synthesis. We hypothesize that retinol depletion and resulting impaired retinoid signaling play a central role in the COVID-19 pathogenesis that is characteristic for dysregulated immune system, defect in Type I interferon synthesis, severe inflammatory process, and destructive systemic multiorgan involvement. Viral RNA recognition mechanism through RIG-I receptors can quickly consume a large amount of the body's retinoid reserve, which causes the retinol levels to fall below the normal serum levels. This causes retinoid insufficiency and impaired retinoid signaling, which leads to interruption in Type I interferon synthesis and an excessive inflammation. Therefore, reconstitution of the retinoid signaling may prove to be a valid strategy for management of COVID-19 as well for some other chronic, degenerative, inflammatory, and autoimmune diseases.

show abstract

Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation

Cited by 2 publications

References 42 publications

Mapping the proteogenomic landscape enables prediction of drug response in acute myeloid leukemia

Mapping the proteogenomic landscape enables prediction of drug response in acute myeloid leukemia

A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder

Contact Info

Product

Resources

About