Selective inhibition of DNA ligase IV provides additional efficacy to the treatment of anaplastic thyroid cancer
Sathya Neelature Sriramareddy,
Majeed Jamakhani,
Léa Vilanova
et al.
Abstract:BackgroundAlthough the incidence of anaplastic thyroid carcinoma (ATC) is low (2.5% of thyroid cancer cases), this cancer has a very poor prognosis (survival rates < 5 months) and accounts for 14–39% of deaths. Conventional therapies based on surgery in combination with radiotherapy or chemotherapy showed limited effectiveness primarily due to the robust and protective DNA damage response in thyroid cancer cells.MethodsWe used single-cell transcriptomic data from patients with different subtypes of thyr… Show more
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