2019
DOI: 10.1111/xen.12536
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Selective inhibition of cyclooxygenase‐2 protects porcine aortic endothelial cells from human antibody‐mediated complement‐dependent cytotoxicity

Abstract: Background Cyclooxygenase‐2 (COX‐2) is an inducible enzyme with catalytic activity for biosynthesis of prostaglandins which are the key mediators of inflammation. COX‐2 is also the therapeutic target for widely used non‐steroidal anti‐inflammatory drugs (NSAIDs). However, the involvement of COX‐2 in xenotransplantation (eg, pig‐to‐non‐human primate) remains poorly recognized. Methods We investigated the mechanisms that regulate COX‐2 expression and the effects of COX‐2 on porcine aortic endothelial cell (PAEC)… Show more

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Cited by 4 publications
(3 citation statements)
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References 65 publications
(132 reference statements)
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“…Given the challenges associated with ongoing attempts to engineer transplantable pig organs by means of genetic engineering 62 or whole organ perfusion decellularization/recellularization 63 , we believe that our approach (illustrated in Fig. 6 ) may provide a significant shortcut in the efforts to generate an unlimited supply of transplantable, immunologically-acceptable organs for future translation into clinical practice.…”
Section: Discussionmentioning
confidence: 99%
“…Given the challenges associated with ongoing attempts to engineer transplantable pig organs by means of genetic engineering 62 or whole organ perfusion decellularization/recellularization 63 , we believe that our approach (illustrated in Fig. 6 ) may provide a significant shortcut in the efforts to generate an unlimited supply of transplantable, immunologically-acceptable organs for future translation into clinical practice.…”
Section: Discussionmentioning
confidence: 99%
“…Another important member of the cytokine family associated with COVID-19 is interleukin-1β, a key regulator of inflammatory response, with the ability to stimulate the release of other cytokines such as IL-17, IL-21, and IL-22. Interleukin-1β and tumor necrosis factor alpha both contribute to pain associated with inflammation via the induction of cyclooxygenase-2 in the nervous system [27]. This may play a role in the severe headache associated with COVID-19 infection.…”
Section: Pro-inflammatory Cytokinesmentioning
confidence: 99%
“…However, the exact mechanism that regulates COX‐2 expression and the function of COX‐2 on PAECs remain unknown. Chen et al aimed to investigate this using an in vitro pig‐to‐primate xenotransplantation model and an in vivo pig‐to‐mouse cellular transplant model . Human serum‐induced COX‐2 expression in PAECs increased in a time‐ and dose‐dependent manner.…”
Section: Improving Xenograft Outcomes Through Genetic Modificationsmentioning
confidence: 99%