Selective Inhibition by α-Tocopherol of Vascular Cell Adhesion Molecule-1 Expression in Human Vascular Endothelial Cells

Effects of Keishibukuryogan on Vascular Function in Adjuvant-Induced Arthritis Rats

“…33) There are some reports that antioxidants such as a-tocopherol and probucol restrict the expression of VCAM-1 on HUVEC. 34,35) In our study, keishibukuryogan suppressed the expression of VCAM-1 on aorta significantly, improving endothelial dysfunction in AIA rats. As a result, we supposed that keishibukuryogan might protect the endothelium by restricting VCAM-1 expression.…”

Selective serotonin re-uptake inhibitors decrease the cytokine-induced endothelial adhesion molecule expression, the endothelial adhesiveness to monocytes and the circulating levels of vascular adhesion molecules

“…Then, TNF-alpha (1 ng/ml) was added and cells were incubated for another 6 h period. Confluent HAEC incubated with α-tocopherol (2 × 10 − 5 M) plus TNF-alpha (1 ng/ml) served as positive control since α-tocopherol decreases the TNF-alpha induced endothelial expression of both VCAM-1 and ICAM-1 [19]. Cells without TNF-alpha and compounds comprised the control cells.…”

Role of Oxidized Lipids in Atherosclerosis

“…-Tocopherol is reported to reduce plasma OxLDL levels at 25 IU/day in both men and women, and the effect rises with increased supplementation until 800 IU/day (Princen et al, 1995). Tocopherol accumulation in monocytes decreases stress-induced adhesion of monocytes to endothelial cells (Islam et al, 1998;Devraj et al, 1996;Faruqi et al, 1994;Zapolska-Downar et al, 2000), which in turn inhibit the formation of atherosclerotic lesions. Overall, a number of in vitro studies demonstrate anti-atherogenic effect of vitamin E by decreasing the production of ROS, lipid oxidation, monocyte endothelial cell adhesion and cytokines secretion.…”