Selective Infrared Neural Inhibition Can Be Reproduced by Resistive Heating

Zhuo, Junqi; Weidrick, Chloe E.; Liu, Yehe; Moffitt, Michael; Jansen, E. Duco; Chiel, Hillel J.; Jenkins, Michael W.

doi:10.1016/j.neurom.2022.12.004

Cited by 2 publications

(3 citation statements)

References 88 publications

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“…Because inhibitory PBM operates at higher irradiances than standard PBM, possible thermal effects are considered. Our team has studied both PBM‐induced neural inhibition (present study) and small‐fiber block via an explicitly heat‐based mechanism (using either infrared‐induced or resistive heating) 39–42 . Heat‐induced and PBM‐induced neural inhibition both selectively silence small nerve fiber activity, but the character of the block is fundamentally different.…”

Section: Discussionmentioning

confidence: 99%

“…neural inhibition (present study) and small-fiber block via an explicitly heat-based mechanism (using either infrared-induced or resistive heating). [39][40][41][42] Heat-induced and PBM-induced neural inhibition both selectively silence small nerve fiber activity, but the character of the block is fundamentally different. In particular, the heat-induced block consists of a rapid onset upon reaching a temperature elevation threshold (threshold ~2.9°C; tested up to 7°C, see Eliasson et al 43 ) and a rapid return to normal firing activity when the heat source is removed.…”

Section: Thermal Response Considerationsmentioning

confidence: 99%

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Selective neural inhibition via photobiomodulation alleviates behavioral hypersensitivity associated with small sensory fiber activation

Buzza,

Tapas,

Zhuo

et al. 2024

Lasers Surg Med

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ObjectivePhotobiomodulation at higher irradiances has great potential as a pain‐alleviating method that selectively inhibits small diameter nerve fibers and corresponding sensory experiences, such as nociception and heat sensation. The longevity and magnitude of these effects as a function of laser irradiation parameters at the nerve was explored.MethodsIn a rodent chronic pain model (spared nerve injury—SNI), light was applied directly at the sural nerve with four delivery schemes: two irradiance levels (7.64 and 2.55 W/cm2) for two durations each, corresponding to either 4.8 or 14.4 J total energy, and the effect on sensory hypersensitivities was evaluated.ResultsAt emitter irradiances of 7.64 W/cm2 (for 240 s), 2.55 W/cm2 (for 720 s), and 7.64 W/cm2 (for 80 s) the heat hypersensitivity was relieved the day following photobiomodulation (PBM) treatment by 37 ± 8.1% (statistically significant, p < 0.001), 26% ± 6% (p = 0.072), and 28 ± 6.1% (statistically significant, p = 0.032), respectively, and all three treatments reduced the hypersensitivity over the course of the experiment (13 days) at a statistically significant level (mixed‐design analysis of variance, p < 0.05). The increases in tissue temperature (5.3 ± 1.0 and 1.3 ± 0.4°C from 33.3°C for the higher and lower power densities, respectively) at the neural target were well below those typically associated with permanent action potential disruption.ConclusionsThe data from this study support the use of direct PBM on nerves of interest to reduce sensitivities associated with small‐diameter fiber activity.

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Section: Discussionmentioning

confidence: 99%

Section: Thermal Response Considerationsmentioning

confidence: 99%

Selective neural inhibition via photobiomodulation alleviates behavioral hypersensitivity associated with small sensory fiber activation

Buzza,

Tapas,

Zhuo

et al. 2024

Lasers Surg Med

Self Cite

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“…Based on this photothermal mechanism, INS has been applied in various targets in both peripheral and central nervous systems, as for instance in the auditory system acutely [12][13][14] and chronically 15 , in the vestibular and facial nerves [16][17][18] , ex vivo on pleural-abdominal connective nerves in the frame of neural inhibition 19 , but also for cardiac pacing 20,21 . In the central nervous system (CNS), INS has demonstrated success in various applications within the cortex.…”

Section: Introductionmentioning

confidence: 99%

Infrared Neuroglial Modulation of spinal locomotor networks

Dumas,

Pecchi,

O'Connor

et al. 2024

Preprint

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Infrared neural stimulation (INS) emerges as a promising tool for stimulating the nervous system by its high spatial precision and absence of the use of exogenous agents into the tissue, which led to the first successful proof of concept in human brain. While neural networks have been the focal point of INS research, this technique is also non cell type specific as it triggers activity in non electrically excitable cells. Despite increasing interest, there remains to demonstrate well defined simultaneous astrocytic and neuronal signals in response to INS. Using intravital calcium imaging, we show that INS has the capacity to initiate calcium signaling in both astrocytes and neurons simultaneously from the rostral lumbar spinal cord, each exhibiting distinct temporal and amplitude characteristics. Importantly, the mechanism underlying infrared-induced neuronal and astrocytic calcium signaling differ, with neuronal activity relying on sodium channels, whereas induced astrocytic signaling is predominantly influenced by extracellular calcium and TRPV4 channels. Furthermore, our findings demonstrate the frequency shift of neuronal calcium oscillations through infrared stimulation. By deepening our understanding in INS fundamentals, this technique holds great promise for advancing neuroscience, deepening our understanding of pathologies, and potentially paving the way for future clinical applications.

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Selective Infrared Neural Inhibition Can Be Reproduced by Resistive Heating

Cited by 2 publications

References 88 publications

Selective neural inhibition via photobiomodulation alleviates behavioral hypersensitivity associated with small sensory fiber activation

Selective neural inhibition via photobiomodulation alleviates behavioral hypersensitivity associated with small sensory fiber activation

Infrared Neuroglial Modulation of spinal locomotor networks

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