Selective increase in gastric mucosal mRNA encoding basolateral Na-K-2Cl cotransporter following ileostomy in the rat

Hallonquist, Heidi; Cima, Robert R.; Klingensmith, Mary E.; Purdy, M. J.; Delpire, Eric; Zinner, Michael J.; Soybel, David I.

doi:10.1016/s1091-255x(98)80018-8

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…The intestinal segments were longitudinally opened and washed twice with cold PBS to remove the contents. The mucosa was separated from the underlying muscularis by sharp dissection (Klingensmith et al, 1996; Hallonquist et al, 1998). The mucosal tissues and bases of the crypt were immediately frozen and stored in liquid N 2 for further processing.…”

Section: Methodsmentioning

confidence: 99%

Role of eIF3a (eIF3 p170) in intestinal cell differentiation and its association with early development

et al. 2007

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Section: Methodsmentioning

confidence: 99%

Role of eIF3a (eIF3 p170) in intestinal cell differentiation and its association with early development

et al. 2007

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Section: General Hyperplasiamentioning

confidence: 99%

“…Although there are distinct differences between the loss of the large intestine compared with loss of the small intestine, some parallel mechanisms may exist. In animal studies colon resection leads to changes in the gastric mucosa (Hallonquist et al 1998), with a generalised thickening and dilation of the mucosal surface and consequent up-regulation of the gastric acid-producing parietal cells. Changes in the structure of the small intestine are also well documented, with an increased intestinal length and weight, mucosal thickness, villus length and villus cell count (Woo & Nygaard, 1978; Willis et al 2002).…”

Section: Gastrointestinal Adaptationmentioning

confidence: 99%

“…This selectivity is intimately related to Na + depletion. There is selective up-regulation of the Na co-transporters, Na–K–2Cl co-transporter in the gastric mucosa (Hallonquist et al 1998) and the electrogenic Na–glucose co-transporter 1 in the small intestine (Haneda et al 2006), and molecular induction of all three subunits of the epithelial Na + channel and its cofactor prostasin (Koyama et al 1999), a novel serine protease that may, in conjunction with epithelial Na + channel, accelerate Na + absorption (Adachi et al 2001). Aldosterone is known to increase expression of both Na–K–2Cl and Na + channels in the kidney tubule, and so secondary aldosteronism is likely to be the prime candidate responsible for parallel up-regulation in the gut.…”

Section: Gastrointestinal Adaptationmentioning

confidence: 99%

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Metabolic cross talk between the colon and the periphery: implications for insulin sensitivity

Robertson

2007

Proc. Nutr. Soc.

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Until recently, a glance at a standard undergraduate textbook would have given the impression that the colon was merely a storage organ for faeces and maybe something about the absorption of electrolytes and water. In reality, the colon is a highly-metabolically-active organ, the function of which has implications not only for the remainder of the digestive tract, but also for peripheral organs such as adipose tissue (AT), liver and skeletal muscle. The present review focuses on two distinct but complementary areas: (1) the metabolic adaptation that occurs following surgical removal of colonic tissue; (2) the effect of modulating the colonin situin terms of postprandial metabolism, insulin sensitivity and disease risk. Work in these two areas points to the colon being important in modulating normal tissue insulin sensitivity. The role of fatty acids is central to the insulin sensitivity hypothesis. AT acts as a daily ‘buffer’ for fatty acids. However, following colonic resection there is an apparent change in AT function. There is an increase in the AT lipolysis rate, resulting in the release of excess fatty acids into the circulation and consequently the take up of excess fatty acids into skeletal muscle. This resultant increase in either storage of lipid or its oxidation would result in a reduction in insulin sensitivity. The insulin-sensitising effects of high-fibre diets are also related to changes in AT function and fatty acid metabolism, but manipulating colonic tissuein situallows the mechanisms to be elucidated. This research area is an exciting one, involving the potential role of SCFA (the absorbed by-products of colonic bacterial fermentation) acting directly on peripheral tissues, following the recent identification of G-protein-coupled receptors specific for these ligands.

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Parietal Cell Volume Regulation During Acid Secretion

Seidler¹,

Bachmann²,

Sonnentag³

et al. 2002

Mechanisms and Consequences of Proton Transport

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Selective increase in gastric mucosal mRNA encoding basolateral Na-K-2Cl cotransporter following ileostomy in the rat

Cited by 6 publications

References 11 publications

Role of eIF3a (eIF3 p170) in intestinal cell differentiation and its association with early development

Role of eIF3a (eIF3 p170) in intestinal cell differentiation and its association with early development

Metabolic cross talk between the colon and the periphery: implications for insulin sensitivity

Parietal Cell Volume Regulation During Acid Secretion

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