Selective Immunoglobulin A Deficiency, <b><i>Helicobacter pylori</i></b> Infection, and Strongyloidiasis in a Patient with Adenocarcinoma of the Stomach

Abstract

Selective immunoglobulin A (IgA) deficiency is one of many congenital immunodeficiencies. It is associated with several medical condition. It has been shown to be associated with some types of malignancies, some autoimmune disorders, and even with some infections. Here we report a young male with selective IgA deficiency who also tested positive for &lt;i&gt;Helicobacter pylori&lt;/i&gt; and strongyloidiasis at the time when he was diagnosed with stomach adenocarcinoma. The presence of IgA deficiency with multiple etiological possibilities such as infections and cancer makes this case unusual.

Malignancy‐associated immune responses: Lessons from human inborn errors of immunity

“…Most recently however, Ludviggson and colleagues found that a diagnosis of SIgAD increased the risk of any cancer by 31%, and gastrointestinal cancer specifically by 64%, even when adjusting for conditions strongly related to SIgAD such as Coeliac Disease 122 . sIgA has been shown to be important in regulating the intestinal microbiome, 15, 125 and ensuring that mucosal surfaces are protected from pathogens, 14, 15, 125 so the increased incidence of gastrointestinal cancers in patients with SIgAD may be due to intestinal microbiome dysregulation due to decreased sIgA 122 . Additionally, SIgAD may also progress to CVID, suggesting that they are both part of the same spectrum of immune disorders, 126 which may indirectly relate to IgA deficiency and CVID‐associated malignancies.…”