Selective imaging and cancer cell death via pH switchable near-infrared fluorescence and photothermal effects

Zhang, Jingye; Liu, Zining; Lian, Peng; Qian, Jun; Li, Xinwei; Wang, Lu; Fu, Wei; Chen, Liang; Wei, Xunbin; Liu, Cong

doi:10.1039/c6sc00221h

Cited by 104 publications

(54 citation statements)

References 60 publications

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“…Also, the temperature increase could accelerate the DOX molecules to diffuse out of mesoporous channels. It has demonstrated the physiological environment in normal tissue is nearly pH 7.4, but the pH in cancerous tissue can be a little acidic to 6–6.8, and more acidic (pH 5.0–6.0) in the endosomes and lysosomes of cancer cells . Therefore, the DOX‐MMSN/GQDs nanoparticles could prevent anticancer drug releasing in normal tissue during the delivery circulation, while trigger anticancer drug release in cancerous tissue or cancer cells, which could enhance the delivery efficiency and decrease the size effect of toxic anticancer drugs.…”

Section: Resultsmentioning

confidence: 99%

Graphene Quantum Dots‐Capped Magnetic Mesoporous Silica Nanoparticles as a Multifunctional Platform for Controlled Drug Delivery, Magnetic Hyperthermia, and Photothermal Therapy

Yao

Niu

et al. 2016

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391

211

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A multifunctional platform is reported for synergistic therapy with controlled drug release, magnetic hyperthermia, and photothermal therapy, which is composed of graphene quantum dots (GQDs) as caps and local photothermal generators and magnetic mesoporous silica nanoparticles (MMSN) as drug carriers and magnetic thermoseeds. The structure, drug release behavior, magnetic hyperthermia capacity, photothermal effect, and synergistic therapeutic efficiency of the MMSN/GQDs nanoparticles are investigated. The results show that monodisperse MMSN/GQDs nanoparticles with the particle size of 100 nm can load doxorubicin (DOX) and trigger DOX release by low pH environment. Furthermore, the MMSN/GQDs nanoparticles can efficiently generate heat to the hyperthermia temperature under an alternating magnetic field or by near infrared irradiation. More importantly, breast cancer 4T1 cells as a model cellular system, the results indicate that compared with chemotherapy, magnetic hyperthermia or photothermal therapy alone, the combined chemo-magnetic hyperthermia therapy or chemo-photothermal therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells. Therefore, the MMSN/GQDs multifunctional platform has great potential in cancer therapy for enhancing the therapeutic efficiency.

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Section: Resultsmentioning

confidence: 99%

Graphene Quantum Dots‐Capped Magnetic Mesoporous Silica Nanoparticles as a Multifunctional Platform for Controlled Drug Delivery, Magnetic Hyperthermia, and Photothermal Therapy

Yao

Niu

et al. 2016

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391

211

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“…The D–A conjugated semiconducting polymer PPor was synthesized via microwave‐assisted Stille‐coupling copolymerization from 5,6‐difluoro‐4,7‐bis[5‐(trimethylstannyl) thiophen‐2‐yl]benzo‐2,1,3‐thiadiazole (as an electron acceptor), 5,5′‐dibromo‐4,4′‐bis(2‐octyldodecyl)‐2,2′‐bithiophene (as an electron donor) and porphyrin–pyrene pendant ( Figure a), as reported in our previous work . Such a D–A based molecular architecture is conducive to introducing intramolecular charge transfer to redshift and enhance the Q‐band absorption, resulting in broadened absorption and increased extinction coefficient which can be beneficial to PTT . It was shown that the porphyrin–pyrene pendant acts as a light‐harvesting unit to greatly enhance the photoinduced charge generation in polymeric solar cell .…”

Section: Resultsmentioning

confidence: 99%

Biocompatible D–A Semiconducting Polymer Nanoparticle with Light‐Harvesting Unit for Highly Effective Photoacoustic Imaging Guided Photothermal Therapy

Zhang

Yang

Zhang

et al. 2017

Adv Funct Materials

193

161

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The development of nanotheranostic agents that integrate diagnosis and therapy for effective personalized precision medicine has obtained tremendous attention in the past few decades. In this report, biocompatible electron donor–acceptor conjugated semiconducting polymer nanoparticles (PPor-PEG NPs) with light-harvesting unit is prepared and developed for highly effective photoacoustic imaging guided photothermal therapy. To the best of our knowledge, it is the first time that the concept of light-harvesting unit is exploited for enhancing the photoacoustic signal and photothermal energy conversion in polymer-based theranostic agent. Combined with additional merits including donor–acceptor pair to favor electron transfer and fluorescence quenching effect after NP formation, the photothermal conversion efficiency of the PPor-PEG NPs is determined to be 62.3%, which is the highest value among reported polymer NPs. Moreover, the as-prepared PPor-PEG NP not only exhibits a remarkable cell-killing ability but also achieves 100% tumor elimination, demonstrating its excellent photothermal therapeutic efficacy. Finally, the as-prepared water-dispersible PPor-PEG NPs show good biocompatibility and biosafety, making them a promising candidate for future clinical applications in cancer theranostics.

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“…Thus, triphenylphosphine structures have been connected to cyanine dyes to make them localize at cell mitochondria, albeit without efficient selectivity for specific cancer cells. [ 28–31 ] Actually however, most cyanine dyes with positive charge exhibit the structure‐inherent targeting (SIT) of mitochondria and can achieve better tumor‐cell‐killing effects by PTT. [ 32–34 ] Furthermore, breast cancer is closely related to estrogen receptor (ER) overexpression in most situations.…”

Section: Introductionmentioning

confidence: 99%

A Single Molecule Drug Targeting Photosensitizer for Enhanced Breast Cancer Photothermal Therapy

Zou

Xiong

et al. 2020

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Targeting is one of the most important strategies for enhancing the efficacy of cancer photothermal therapy (PTT) and reducing damage to surrounding normal tissues. Compared with the traditional targeting approaches, the active targeting of breast cancer cells in PTT using chemotherapeutic drugs, such as tamoxifen (TAM), in combination with single‐molecule photothermal photosensitizers has superior selectivity and therapeutic effects. However, single‐molecule drug‐targeting photosensitizers for improved PTT efficacy are not widely reported. Accordingly, herein, a near‐infrared induced small‐molecule photothermal photosensitizer (CyT) is developed that actively targets the estrogen receptors (ERs) of breast cancer cells as well as targets mitochondria by structure‐inherent targeting. Cell uptake and cytotoxicity studies using different types of cells show that CyT enhances the efficiency of TAM‐based PTT by targeting ER‐overexpressing breast cancer cells and selectively killing them. In vivo experiments demonstrate that CyT can be used as a photothermal agent for fluorescence imaging‐guided PTT. More importantly, the intravenous injection of CyT results in better targeting and efficiency of tumor inhibition compared with that achieved with the TAM‐free control molecule Cy. Thus, the study presents an excellent small‐molecule photothermal agent for breast cancer therapy with potential clinical application prospects.

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Selective imaging and cancer cell death via pH switchable near-infrared fluorescence and photothermal effects

Abstract: A theranostic probe is designed that specifically illuminates and photoablates cancer cells by sensing pH changes in the lysosomes and mitochondria.

Cited by 104 publications

References 60 publications

Graphene Quantum Dots‐Capped Magnetic Mesoporous Silica Nanoparticles as a Multifunctional Platform for Controlled Drug Delivery, Magnetic Hyperthermia, and Photothermal Therapy

Graphene Quantum Dots‐Capped Magnetic Mesoporous Silica Nanoparticles as a Multifunctional Platform for Controlled Drug Delivery, Magnetic Hyperthermia, and Photothermal Therapy

Biocompatible D–A Semiconducting Polymer Nanoparticle with Light‐Harvesting Unit for Highly Effective Photoacoustic Imaging Guided Photothermal Therapy

A Single Molecule Drug Targeting Photosensitizer for Enhanced Breast Cancer Photothermal Therapy

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