Selective hippocampal complex deafferentation and deefferentation and avoidance behavior in rats

Hoesen, Gary W. Van; Wilson, Linda M.; MacDougall, James M.; Mitchell, James C.

doi:10.1016/0031-9384(72)90299-5

Cited by 56 publications

(9 citation statements)

References 18 publications

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“…Routtenberg and Kramis (1968) found that aversive midbrain stimulation in the periventricular area of the midbrain reliably produced theta trains in the hippocampal EEG. Unfortunately, hippocampal rats have not been specifically tested for their response to frightening stimuli, although in avoidance tasks (e.g., passive avoidance) animals with hippocampal or cingulate lesions are seriously deficient (McCleary 1966;Van Hoesen, Wilson, MacDougall & Mitchell 1972). Different neural systems may be involved in avoidance, depending on the nature of the response required (see Vanderwolf 1983).…”

Section: Avoidancementioning

confidence: 99%

Relationships between the superior colliculus and hippocampus: Neural and behavioral considerations

Foreman

Stevens

1987

Behav Brain Sci

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Theories of superior collicular and hippocampal function have remarkable similarities. Both structures have been repeatedly implicated in spatial and attentional behaviour and in inhibitory control of locomotion. Moreover, they share certain electrophysiological properties in their single unit responses and in the synchronous appearance and disappearance of slow wave activity. Both are phylogenetically old and the colliculus projects strongly to brainstem nuclei instrumental in the generation of theta rhythm in the hippocampal EECOn the other hand, close inspection of behavioural and electrophysiological data reveals disparities. In particular, hippocampal processing mainly concerns stimulus ambiguity, contextual significance, and spatial relations or other subtle, higher order characteristics. This requires the use of largely preprocessed sensory information and mediation of poststimulus investigation. Although collicular activity must also be integrated with that of “higher” centres (probably to a varying degree, depending on the nature of stimuli being processed and the task requirements), its primary role in attention is more “peripheral” and specific in controlling orienting/localisation via eye and body movements toward egocentrically labelled spatial positions. In addition, the colliculus may exert a nonspecific influence in alerting higher centres to the imminence of information potentially worthy of focal attention. Nevertheless, it is noteworthy that collicular and hippocampal lesions produce deficits on similar tasks, although the type of deficit is usually different (often opposite) in each case. Functional overlap between hippocampus and colliculus (i.e., strategically synchronised or mutually interdependent activity) is virtually certain vis-à-vis stimulus sampling, for example in the acquisition of information via vibrissal movements and visual scanning. In addition, insofar as stimulus significance is a factor in collicular orienting mechanisms, the hippocampus — cingulate – cortex — colliculus pathway may play a significant role, modulating collicular responsiveness and thus ensuring an attentional strategy appropriate to current requirements (stimulus familiarity, stage of learning). A tentative “reciprocal loop” model is proposed which bridges physiological and behavioural levels of analysis and which would account for the observed degree and nature of functional overlap between the superior colliculus and hippocampus.

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Section: Avoidancementioning

confidence: 99%

Relationships between the superior colliculus and hippocampus: Neural and behavioral considerations

Foreman

Stevens

1987

Behav Brain Sci

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“…This does not preclude the possibility that destruction of other neural structures and fiber systems associated with the hippocampus contributes to the behavioral effects of large hippocampal or total fornix lesions. Indeed, damage to the entorhinal cortex, which projects to the hippocampus via the performant path, results in enhanced active avoidance acquisition (Van Hoesen, Wilson, MacDougall, & Mitchell, 1972), deficits in learning a complex maze (Olton, Walker, & Gage, 1978), and impaired passive avoidance learning (Van Hoesen et al, 1972). Also, elimination of the serotonergic input to the hippocampus by transection of the ascending monoamine fibers (Ross & Grossman, 1975a, 1975b, or by lesions of the median raphe nucleus (Asin, Wirtshafter, & Kent, 1979), produces effects on several behaviors which are similar to effects reported after hippocampal destruction.…”

Section: Discussionmentioning

confidence: 99%

Transection of direct anterior thalamic afferents from the hippocampus: Effects on activity and active avoidance in rats.

Davis¹

1979

Journal of Comparative and Physiological Psychology

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This investigation demonstrates the importance of the direct hippocampoanterior thalamic component of the postcommissural fornix in the control of general locomotion and active avoidance. Transection of anterior thalamic afferents from the hippocampal formation (subicular cortex), at the point where they exit from the fornix posterior to the septum, is sufficient to enhance bidirectional active avoidance acquisition and increase general activity. This transection may also interrupt fibers to or from other thalamic nuclei and the anterior septum. However, destruction of connections of the anterior septum with the hippocampus, habenula, and thalamus by transection in the coronal plane anterior to the descending fornix columns, without damage to the subiculothalamic fibers, increases general activity levels without affecting active avoidance behavior. The activity increase in this case resembles that seen after septal lesions rather than that seen after hippocampal lesions. Thus, destruction of a single fornix component contributing afferents to the anterior thalamic nuclei reproduces at least part of the hippocampal syndrome. This suggests that these fibers contribute significantly to the control of these behaviors and may mediate active avoidance changes resulting from hippocampal and fornix damage.Previous investigations have demonstrated similarities in the behavioral effects of hippocampal and septal lesions. Damage to these areas is known to elevate activity levels (reviewed by Douglas, 1967;Kimble, 1968), facilitate active avoidance acquisition (Isaacson, Douglas & Moore, 1961;King, 1958), and impair performance on a differential reinforcement of low rate schedule (Clark & Isaacson, 1965;Ellen, Wilson, & Powell, 1964). Many of these effects are replicated by selective transection of the major fiber systems innervating the hippocampus and septum, particularly the reciprocal connections of the hippocampal formation and septum in the fornix-fimbrial complex (MacDougall & Capobianco,

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“…However, the existence of direct prefrontal afferents to the hippocampal formation is significant, for it may help to explain not only the influence of granular frontal cortex on archicortical mechanisms relat ed to learning and memory (and perhaps emotional) behaviors, but also resolve some of the understandable frustrations encountered in attempts to deafferent the hippocampus strictly by using entorhinal and fornical le sions [25].…”

Section: Discussionmentioning

confidence: 99%

Preliminary Evidence for a Direct Projection of the Prefrontal Cortex to the Hippocampus in the Squirrel Monkey

Leichnetz¹,

Astruc²

1975

Brain Behav Evol

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Unilateral partial ablations in the medial prefrontal cortex of six squirrel monkeys led to fiber degeneration which followed cingulate and uncinate routes to the hippocampal region. Degenerating fibers were observed primarily in the alvear, but also in the perforant, bundle. Preterminal and terminal debris was seen on basket cells of the stratum oriens and pyramidal cells within the stratum pyramidalis of CA _1–3, Since the prefrontal cortex has been shown to receive convergent sensory inputs from both external and internal milieu, this projection may represent the anatomical substrate for the essential influence of this information on the hippocampus proper, and also explain data which show the prefrontal cortex and hippocampus to be integrally related to mechanisms of learning and memory behavior.

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Selective hippocampal complex deafferentation and deefferentation and avoidance behavior in rats

Cited by 56 publications

References 18 publications

Relationships between the superior colliculus and hippocampus: Neural and behavioral considerations

Relationships between the superior colliculus and hippocampus: Neural and behavioral considerations

Transection of direct anterior thalamic afferents from the hippocampus: Effects on activity and active avoidance in rats.

Preliminary Evidence for a Direct Projection of the Prefrontal Cortex to the Hippocampus in the Squirrel Monkey

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