Selective H+-Dependent Release of Contents from Thymine-Labeled Phospholipid Vesicles by an Adenine-Labeled Polyelectrolyte

Pinilla, Inmaculada Molina; Martı́nez, Manuel Bueno; Tirrell, David A.

doi:10.1021/ma00088a004

Cited by 11 publications

(7 citation statements)

References 6 publications

(8 reference statements)

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“…Protein adsorption onto a solid substrate involves hydrophobic, van der Waals, ionic, and hydrogen bonding interactions, with the pH and ionic strength playing significant roles in adsorption. [10][11][12][13][14] The protein adsorption analysis was carried out in PBS buffer solutions prepared at pH 5 4.5, 7.4, and 10.5, using SPR spectroscopy. The representative SPR spectroscopy data are shown in Figure 5.…”

Section: Figurementioning

confidence: 99%

“…[2][3][4] Significant research efforts have been applied toward nucleobase functionalization for the development of polymers that select and bind to complementary partners or that provide a compatible and benign interface with biological systems. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Several polymers containing nucleobase moieties have been developed, with backbones composed of polyethylenimine, polyacrylate, polymethacrylate, poly(methyl methacrylate), polystyrene, polyvinylbenzyl, polynorbornene, or polypeptides. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] The polymers primarily display amorphous material characteristics.…”

mentioning

confidence: 99%

“…[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Several polymers containing nucleobase moieties have been developed, with backbones composed of polyethylenimine, polyacrylate, polymethacrylate, poly(methyl methacrylate), polystyrene, polyvinylbenzyl, polynorbornene, or polypeptides. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] The polymers primarily display amorphous material characteristics. They have been tested as biomaterials, 5 in molecular recognition applications, [6][7][8][9][10][11][12][13][14][15] in template polymerization applications, [16][17][18] and as catalysts.…”

mentioning

confidence: 99%

“…[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] The polymers primarily display amorphous material characteristics. They have been tested as biomaterials, 5 in molecular recognition applications, [6][7][8][9][10][11][12][13][14][15] in template polymerization applications, [16][17][18] and as catalysts. [19][20][21] However, the biomaterial characteristics of the polymers have not been extensively examined.…”

mentioning

confidence: 99%

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Synthesis, physicochemical characteristics, and biocompatibility of self-assemble polymers bearing guanine, cytosine, uracil, and thymine moieties

Kim

Jung

et al. 2015

J. Polym. Sci. Part A: Polym. Chem.

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ABSTRACT:We synthesized chemically well-defined brush (i.e., comb-like) polymers bearing guanine, cytosine, uracil, or thymine moieties at the bristle ends. The polymers were stable up to 220 C and were readily solution-processable, yielding highquality films. Interestingly, the brush polymers favorably selfassembled to form molecular multibilayer structures stabilized by hydrogen bonding interactions among the nucleobase moieties at the bristle ends, which provided nucleobase-rich surfaces. The multibilayer-structured polymer films showed high water affinity. They also displayed selective protein adsorption, suppressed bacterial adherence, facilitated cell adhesion, and exhibited good biocompatibility in mice. The brush polymer DNA-mimicking comb-like polymers are suitable as biomaterials and in protein separation applications.

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Section: Figurementioning

confidence: 99%

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confidence: 99%

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Synthesis, physicochemical characteristics, and biocompatibility of self-assemble polymers bearing guanine, cytosine, uracil, and thymine moieties

Kim

Jung

et al. 2015

J. Polym. Sci. Part A: Polym. Chem.

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“…Tirrell has shown that poly(2-ethylacrylic acid) (PEAA) could bind to multilamellar vesicles including liposomes in a pH-dependent manner, and induce the release of probe molecules [60][61][62]. It is believed that at acidic pH as the carboxylic acid groups become protonated, and as the polymer becomes more hydrophobic and surface adsorption increases [63].…”

confidence: 99%

Development of acid-sensitive copolymer micelles for drug delivery

Gillies

Fréchet

2004

Pure and Applied Chemistry

115

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In recent years, supramolecular micellar assemblies formed from amphiphilic block copolymers have been receiving attention as potential drug carriers. The size of the carriers is ideal for avoiding rapid renal exclusion and reticuloendothelial uptake, and enables them to be targeted to certain tissues such as tumors. One important issue determining the effectiveness of a micellar drug carrier is the ability to control the time over which drug release takes place, or to possibly trigger drug release at a specific location or time. The mildly acidic pH encountered in tumor and inflammatory tissues as well as in the endosomal and lysosomal compartments of cells has inspired the development of micellar carriers capable of releasing their drug load in response to small changes in pH. One approach to the development of these systems has been to incorporate "titratable" groups such as amines and carboxylic acids into the copolymer backbone, thus altering the solubility of the polymer upon protonation and disrupting micelle formation. Another approach has been to incorporate aciddegradable linkages into the copolymer, either for direct attachment of the drug, or to cause a structural change of such magnitude that micellar integrity is lost and the drug is released.

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Dimension of heterogeneous network architecture formed in emulsion cross‐linking copolymerization

Tobita

2023

Can J Chem Eng

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The mean‐square radius of gyration Rg2 and the graph diameter D of highly heterogeneous network polymers formed in emulsion vinyl/divinyl copolymerization are investigated to find a linear relationship, Rg2 = a D. The proportionality coefficient, a, is dominated by the cycle (circuit) rank, kc, or the number of intramolecular cross‐links. The magnitude of a is slightly larger than that for the random cross‐linked network polymers, but the functional form of a (kc) is simply proportional to that for the random networks proposed earlier. This relationship makes it possible to determine Rg2 based on D and kc, enabling quick estimation of Rg2 for large network polymers. It is found that the contraction factor g of the present heterogeneous network polymer is larger than that for the homogeneous networks formed through random cross‐linking of polymer chains. The ratio of these two contraction factors is kept constant, irrespective of the magnitude of kc.

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Selective H+-Dependent Release of Contents from Thymine-Labeled Phospholipid Vesicles by an Adenine-Labeled Polyelectrolyte

Cited by 11 publications

References 6 publications

Synthesis, physicochemical characteristics, and biocompatibility of self-assemble polymers bearing guanine, cytosine, uracil, and thymine moieties

Synthesis, physicochemical characteristics, and biocompatibility of self-assemble polymers bearing guanine, cytosine, uracil, and thymine moieties

Development of acid-sensitive copolymer micelles for drug delivery

Dimension of heterogeneous network architecture formed in emulsion cross‐linking copolymerization

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