Selective Formation of Porous Pt Nanorods for Highly Electrochemically Efficient Neural Electrode Interfaces

Ganji, Mehran; Paulk, Angelique C.; Yang, Jimmy C.; Vahidi, Nasim W.; Lee, Sang‐Heon; Liu, Ren; Hossain, Lorraine; Arneodo, Ezequiel M.; Thunemann, Martin; Shigyo, Michiko; Tanaka, Atsunori; Ryu, Sang Baek; Lee, Seung Woo; Tchoe, Youngbin; Maršala, Martin; Devor, Anna; Cleary, Daniel R.; Martin, Joel R.; Oh, Hongseok; Gilja, Vikash; Gentner, Timothy Q.; Fried, Shelley I.; Halgren, Eric; Cash, Sydney S.; Dayeh, Shadi A.

doi:10.1021/acs.nanolett.9b02296

Cited by 54 publications

(63 citation statements)

References 37 publications

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“…One advantage of using CRFs generated from the MNE quadratic model versus receptive fields generated by linear models is that CRFs capture more variation in natural stimuli. As a result, their spectrograms are visually more similar to the spectrograms of bird songs (Figure 7B-F) (Ganji et al, 2019;Vahidi, 2019). Another advantage of CRFs over LRFs is that multiple CRFs can be extracted for each cell's response, whereas LRFs are limited to one feature per cell.…”

Section: Introductionmentioning

confidence: 81%

Spatial and Temporal Organization of Composite Receptive Fields in the Songbird Auditory Forebrain

Vahidi

2021

Preprint

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The mechanisms underlying how single auditory neurons and neuron populations encode natural and acoustically complex vocal signals, such as human speech or bird songs, are not well understood. Classical models focus on individual neurons, whose spike rates vary systematically as a function of change in a small number of simple acoustic dimensions. However, neurons in the caudal medial nidopallium (NCM), an auditory forebrain region in songbirds that is analogous to the secondary auditory cortex in mammals, have composite receptive fields (CRFs) that comprise multiple acoustic features tied to both increases and decreases in firing rates. Here, we investigated the anatomical organization and temporal activation patterns of auditory CRFs in European starlings exposed to natural vocal communication signals (songs). We recorded extracellular electrophysiological responses to various bird songs at auditory NCM sites, including both single and multiple neurons, and we then applied a quadratic model to extract large sets of CRF features that were tied to excitatory and suppressive responses at each measurement site. We found that the superset of CRF features yielded spatially and temporally distributed, generalizable representations of a conspecific song. Individual sites responded to acoustically diverse features, as there was no discernable organization of features across anatomically ordered sites. The CRF features at each site yielded broad, temporally distributed responses that spanned the entire duration of many starling songs, which can last for 50 s or more. Based on these results, we estimated that a nearly complete representation of any conspecific song, regardless of length, can be obtained by evaluating populations as small as 100 neurons. We conclude that natural acoustic communication signals drive a distributed yet highly redundant representation across the songbird auditory forebrain, in which adjacent neurons contribute to the encoding of multiple diverse and time-varying spectro-temporal features.

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Section: Introductionmentioning

confidence: 81%

Spatial and Temporal Organization of Composite Receptive Fields in the Songbird Auditory Forebrain

Vahidi

2021

Preprint

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“…[ 114 ] Therefore, an ideal electrode should have low resistance and good biocompatibility, cannot cause the death of surrounding cells or produce harmful byproducts during the charge‐transfer process, and be compatible with soft human tissues to prevent fibrosis. [ 115 ] Recently, various strategies to obtain an ideal wired device have been developed, both in the design of traditional rigid electrodes [ 116 ] and more advanced flexible electrodes. [ 117 ]…”

Section: Advanced Designs Of Implants With Charge‐transfer Monitoring or Regulating Abilitiesmentioning

confidence: 99%

Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities

et al. 2021

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Transmembrane charge (ion/electron) transfer is essential for maintaining cellular homeostasis and is involved in many biological processes, from protein synthesis to embryonic development in organisms. Designing implant devices that can detect or regulate cellular transmembrane charge transfer is expected to sense and modulate the behaviors of host cells and tissues. Thus, charge transfer can be regarded as a bridge connecting living systems and human‐made implantable devices. This review describes the mode and mechanism of charge transfer between organisms and nonliving materials, and summarizes the strategies to endow implants with charge‐transfer regulating or monitoring abilities. Furthermore, three major charge‐transfer controlling systems, including wired, self‐activated, and stimuli‐responsive biomedical implants, as well as the design principles and pivotal materials are systematically elaborated. The clinical challenges and the prospects for future development of these implant devices are also discussed.

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“…However, the small geometrical sizes also limit the electrical functions of the microelectrodes, and increased impedance and reduced charge injection properties are associated with the microelectrodes compared to the bulky ones. To address this issue, the geometric surface of the microelectrodes can be miniaturized to form conductive, porous, and biocompatible nanostructures [62]. Strategies to improve the electrochemical surface area whilst maintaining the desired geometric area include the development of rough microelectrodes and microelectrode coatings onto traditional planar microelectrode materials such as gold and platinum.…”

Section: Conducting Polymer-based Compositementioning

confidence: 99%

Conducting Polymer-Based Composite Materials for Therapeutic Implantations: From Advanced Drug Delivery System to Minimally Invasive Electronics

Liu

Yin

Chen

et al. 2020

International Journal of Polymer Science

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Conducting polymer-based composites have recently becoming popular in both academic research and industrial practices due to their high conductivity, ease of process, and tunable electrical properties. The multifunctional conducting polymer-based composites demonstrated great application potential for in vivo therapeutics and implantable electronics, including drug delivery, neural interfacing, and minimally invasive electronics. In this review article, the state-of-the-art conducting polymerbased composites in the mentioned biological fields are discussed and summarized. The recent progress on the synthesis, structure, properties, and application of the conducting polymer-based composites is presented, aimed at revealing the structure-property relationship and the corresponding functional applications of the conducting polymer-based composites. Furthermore, key issues and challenges regarding the implantation performance of these composites are highlighted in this paper.An efficient drug delivery system that can deliver the drug to targeted body sites and control the drug release rate precisely is able to improve the therapeutic outcomes and reduce the side effects [36,37]. Structuring such drug delivery systems has been long dreamed of and became more and more practical with the development of a variety of polymer-based delivery systems. From nonbiodegradable diffusion-controlled membranes [38] to biodegradable systems with a combination of diffusion and polymer matrix degradation [39], the polymer-based delivery system has shown enormous benefits in drug delivery and release. And since the 1980s, an effective and intelligent drug delivery system based on the ICPs has been developed [40,41]. Resulting from their inherent electrical, magnetic, and optical properties, the ICPs, especially their composites, are 2

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Selective Formation of Porous Pt Nanorods for Highly Electrochemically Efficient Neural Electrode Interfaces

Cited by 54 publications

References 37 publications

Spatial and Temporal Organization of Composite Receptive Fields in the Songbird Auditory Forebrain

Spatial and Temporal Organization of Composite Receptive Fields in the Songbird Auditory Forebrain

Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities

Conducting Polymer-Based Composite Materials for Therapeutic Implantations: From Advanced Drug Delivery System to Minimally Invasive Electronics

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