Selective extraction of organophosphorus nerve agent degradation products by molecularly imprinted solid-phase extraction

Moullec, Sophie Le; Bégos, Arlette; Pichon, Valérie; Bellier, Bertrand

doi:10.1016/j.chroma.2005.12.105

Cited by 78 publications

(40 citation statements)

References 31 publications

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“…An MIP selective for sameridine was prepared using a close structural analogue of sameridine as the template. The use of a dummy molecule is particularly advantageous when developing an MIP for class-selective extraction as in the synthesis of MIPs for dopamine [33], atrazine [22], or organophosphorus nerve agents [34]. Other methods, such as thermal decomposition, microwave-…”

Section: Polymer Synthesis and Evaluationmentioning

confidence: 99%

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Molecularly imprinted polymers and their application in solid phase extraction

Lasáková

Jandera

2009

J of Separation Science

127

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Solid phase extraction is routinely used in many different areas of analytical chemistry. Some of the main fields are environmental, biological, and food chemistry, where cleaning and pre-concentration of the sample are important steps in the analytical protocol. Molecularly imprinted polymers (MIPs) have attracted attention because they show promise as compound-selective or group-selective media. The application of these synthetic polymers as sorbents allows not only pre-concentration and cleaning of the sample but also selective extraction of the target analyte, which is important, particularly when the sample is complex and impurities can interfere with quantification. This review surveys the selectivity of MIPs in solid phase extraction of various kinds of analytes.

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Section: Polymer Synthesis and Evaluationmentioning

confidence: 99%

“…This approach was recently used to compare the effect of the amount of porogen on the binding properties of MIPs for cholesterol [58]. The binding characteristics can be evaluated from the equilibrium binding experiments by processing with Scatchard equations [59] or by constructing a saturation capacity curve [34].…”

Section: Mips As Chromatographic Mediamentioning

confidence: 99%

Molecularly imprinted polymers and their application in solid phase extraction

Lasáková

Jandera

2009

J of Separation Science

127

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“…Preconcentration by SPE with propazine-MIP as a sorbent (A); preconcentration by SPE with a mixture of propazine-MIP and LiChrolut EN as a sorbent (B); preconcentration by SPE with LiChrolutEN and a clean-up step with the propazine-MIP (C). Peaks: (1) desisopropylhydroxyatrazine, (2) desethylhydroxyatrazine, (3) DIA, (4) DEA, (5) hydroxyterbutylazine, (6) simazine, (7) atrazine, (8) propazine, (9) terbutylazine, (10) prometryn, and (11) [200] colated through the propazine-MIP in organic media coming from the previous SPE step. As shown in Fig.…”

Section: Environmental Applicationmentioning

confidence: 99%

Molecularly imprinted polymers as affinity‐based separation media for sample preparation

Haginaka¹

2009

J of Separation Science

170

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This review article deals with molecularly imprinted polymers (MIPs) as affinity-based separation media for sample preparation. An over view of two types of MIPs (molecularly imprinted particle and monolith) used for the sample preparation and modes of molecularly imprinted SPE (online mode, offline mode, on-column extraction, SPME, and microextraction in packed syringe) is given, focusing on the advantages and disadvantages of these types and modes. Next, problems (template leakage and incompatibility with aqueous conditions) associated with molecularly imprinted SPE and how to overcome those problems are described. Finally, pharmaceutical, food, bioanalytical, and environmental application of molecularly imprinted SPE will be discussed.

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“…The previous studies [22] had succeeded in construction of semi-covalent strategy based in-situ monolithic polymer membrane based sensor for DCP via single pot synthesis. The extraction of all possible degradation products of the chemical warfare agents using molecularly imprinted polymers were developed by various research groups [20,23,24]. The semi-covalent strategy has been successfully demonstrated in the present study for the fabrication of imprinted polymer inclusion membrane (IPIM) based sensor for the detection and quantification of DCP, a simulant of soman present in spiked natural waters.…”

Section: Introductionmentioning

confidence: 96%

Imprinted Polymer Inclusion Membrane Based Potentiometric Sensor for Determination and Quantification of Diethyl Chlorophosphate in Natural Waters

Vishnuvardhan¹,

Yakkala²,

Prathish³

et al. 2011

AJAC

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Biomimetic potentiometric sensor for the determination of diethyl chlorophosphate was developed using imprinted polymer inclusion membrane strategy. Semi-covalent imprinted and non-imprinted polymer particles were synthesized and found that non-imprinted polymer inclusion membrane was unstable in contrast to imprinted polymer inclusion membrane in determination and quantification of diethyl chlorophosphate. Imprinted polymer inclusion membrane based sensor found to be pH dependant with a 5 min equilibrium response time at pH = 10.5 and linearly responds to diethyl chlorophosphate in the concentration range of 1 × 10 -9 to 1 × 10 -4 and 1 × 10 -4 to 1 × 10 -2 mol·L -1 with a detection limit of 1 × 10 -9 mol·L -1 (0.17 ppb). It was found that diethyl chlorophosphate response was selective against various selected interferents like pinacolyl methylphosphonate, dimethyl methyl phosphonate, methylphosphonic acid, Phorate and 2, 4-D. The developed sensor was found to be stable for 3 months and can be reusable more than 30 times without loosing sensitivity. The developed sensor was successfully applied for the determination of diethyl chlorophosphate in natural waters.

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Selective extraction of organophosphorus nerve agent degradation products by molecularly imprinted solid-phase extraction

Cited by 78 publications

References 31 publications

Molecularly imprinted polymers and their application in solid phase extraction

Molecularly imprinted polymers and their application in solid phase extraction

Molecularly imprinted polymers as affinity‐based separation media for sample preparation

Imprinted Polymer Inclusion Membrane Based Potentiometric Sensor for Determination and Quantification of Diethyl Chlorophosphate in Natural Waters

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