Selective expression of PDGF A and its receptor during early mouse embryogenesis

Mercola, Mark; Wang, Chiayeng; Kelly, James D.; Brownlee, Clare; Jackson-Grusby, Laurie; Stiles, Charles D.; Bowen‐Pope, Daniel F.

doi:10.1016/0012-1606(90)90181-h

Cited by 193 publications

(108 citation statements)

References 35 publications

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“…Probes for Crabp1 (Stoner and Gudas, 1989), Dlx1 (Dolle et al, 1992), Msx1 (Satokata and Maas, 1994), Pdgfa (Mercola et al, 1990), Pdgfc (Ding et al, 2000) and Sox10 (Southard-Smith et al, 1998) were as described previously. Digoxigenin-labeled RNA probes were prepared using reagents from Roche Molecular Biochemicals.…”

Section: Histology and Whole-mount In Situ Hybridizationmentioning

confidence: 99%

Requirement for Foxd3 in the maintenance of neural crest progenitors

et al. 2008

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Understanding the molecular mechanisms of stem cell maintenance is crucial for the ultimate goal of manipulating stem cells for the treatment of disease. Foxd3 is required early in mouse embryogenesis; Foxd3 -/-embryos fail around the time of implantation, cells of the inner cell mass cannot be maintained in vitro, and blastocyst-derived stem cell lines cannot be established. Here, we report that Foxd3 is required for maintenance of the multipotent mammalian neural crest. Using tissue-specific deletion of Foxd3 in the neural crest, we show that Foxd3 flox/-; Wnt1-Cre mice die perinatally with a catastrophic loss of neural crest-derived structures. Cranial neural crest tissues are either missing or severely reduced in size, the peripheral nervous system consists of reduced dorsal root ganglia and cranial nerves, and the entire gastrointestinal tract is devoid of neural crest derivatives. These results demonstrate a global role for this transcriptional repressor in all aspects of neural crest maintenance along the anterior-posterior axis, and establish an unprecedented molecular link between multiple divergent progenitor lineages of the mammalian embryo.

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Section: Histology and Whole-mount In Situ Hybridizationmentioning

confidence: 99%

Requirement for Foxd3 in the maintenance of neural crest progenitors

et al. 2008

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“…2 However, PDGFs are produced by many cell types and also participate in functions other than wound repair. For instance, PDGFs have been implicated in development, [3][4][5][6] and expression of PDGFs in neurons suggests possible neurotrophic and/or gliotrophic effects. 7,8 The PDGF family is made up of dimers of the products from two genes, PDGF-A and PDGF-B, resulting in three family members, PDGF-AA, PDGF-AB, and PDGF-BB.…”

mentioning

confidence: 99%

Platelet-Derived Growth Factor-A-Induced Retinal Gliosis Protects against Ischemic Retinopathy

Yamada

Andõ

et al. 2000

The American Journal of Pathology

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“…Platelet-derived growth factor and its receptors have been found in a number of developing systems, including the mammalian limb (Raff et al, 1988;Mercola et al, 1990;. PDGF is thought to play a role in regulating cell proliferation and differentiation in these developing tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Platelet-derived growth factor (PDGF) inhibits cartilage formation by cultured chick limb bud mesoderm and increases cell proliferation (Chen et al, 1992). PDGF has been implicated as a possible modulator of embryonic differentiation in a variety of systems (Mercola et al, 1988(Mercola et al, , 1990Richardson et al, 1988). In addition, PDGF and its receptors are present during mouse limb development Schatteman et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Selective expression of the chicken platelet‐derived growth factor α (PDGFα) receptor during limb bud development

Potts

Carrington

1993

Developmental Dynamics

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Platelet-derived growth factor (PDGF) affects proliferation and differentiation of chicken limb bud mesoderm in vitro. However, no PDGF receptor has been characterized in the chicken wing bud in vivo. In this study, we used reverse transcription PCR (rtPCR), Northern blot analysis, and Western blot analysis to identify a molecule, in the developing wing bud, which represents the chicken homolog of the PDGFa receptor. The chicken PDGFa receptor mRNA was present in both mesoderm and ectoderm and all stages of the developing limb bud examined. Cultured limb bud mesoderm also expressed the PDGFa receptor transcript. In addition, the PDGFa receptor protein was present in whole limb buds and cultured limb bud mesoderm. Expression of the PDGFa receptor in cultured mesoderm was independent of the presence of ectoderm cells. The relative sizes of both the mRNA and protein for the PDGFa receptor in the chicken limb bud were similar to mammalian counterparts. Using similar approaches, neither the mRNA nor protein representing the chicken homolog of the PDGFp receptor was detected. These data demonstrate for the first time that a PDGFa receptor is present in the embryonic chicken limb bud and may help regulate growth and differentiation of the embryonic limb. 0 1993 Wiley-Liss, Inc.*

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Selective expression of PDGF A and its receptor during early mouse embryogenesis

Cited by 193 publications

References 35 publications

Requirement for Foxd3 in the maintenance of neural crest progenitors

Requirement for Foxd3 in the maintenance of neural crest progenitors

Platelet-Derived Growth Factor-A-Induced Retinal Gliosis Protects against Ischemic Retinopathy

Selective expression of the chicken platelet‐derived growth factor α (PDGFα) receptor during limb bud development

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