Selective Estrogen Receptor Modulator Lasofoxifene Suppresses Spondyloarthritis Manifestation and Affects Characteristics of Gut Microbiota in Zymosan-induced SKG Mice
Abstract:Background: Ankylosing spondylitis is a male-predominant disease and previous study revealed that estrogen has an anti-inflammatory effect on the spondyloarthritis (SpA) manifestations in zymosan-induced SKG mice. This study aimed to evaluate the effect of selective estrogen receptor (ER) modulator lasofoxifene (Laso) on disease activity of SpA. Methods: Mice were randomized into zymosan-treated, zymosan + 17β-estradiol (E2)-treated, and zymosan + Laso-treated groups. Clinical arthritis scores were measured, a… Show more
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