1971
DOI: 10.1093/oxfordjournals.aje.a121325
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Selective Epidemiologic Control in Smallpox Eradication1

Abstract: A change of strategy was instituted in the West and Central Africa Smallpox Eradication Program in the fall of 1968. High priority was given to eliminating smallpox foci rather than limiting activities to mass vaccination. The progress of the program since September 1968 shows that the change in emphasis resulted in active surveillance activities which discovered more smallpox cases than the official reporting system. All known smallpox outbreaks were investigated in 1969. Vaccination totals did not suffer fro… Show more

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Cited by 86 publications
(41 citation statements)
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“…inoculation of NHPs with 5 ϫ 10 7 PFU results in fever and lesion development by mean day 3 and 5, respectively. This is in contrast to human cases of MPXV and variola infection, where fever, malaise, prostration, and subsequent lesion development typically follow an approximately 12-day incubation phase after exposure (13,31). It was hypothesized that peripheral exposure, such as by i.b.…”
Section: Discussionmentioning
confidence: 83%
“…inoculation of NHPs with 5 ϫ 10 7 PFU results in fever and lesion development by mean day 3 and 5, respectively. This is in contrast to human cases of MPXV and variola infection, where fever, malaise, prostration, and subsequent lesion development typically follow an approximately 12-day incubation phase after exposure (13,31). It was hypothesized that peripheral exposure, such as by i.b.…”
Section: Discussionmentioning
confidence: 83%
“…While such vaccination programs were in progress, sufficient time would be provided for surveillance systems to develop. Surprising, however, was the discovery in Nigeria during the first year of the program that an extensive area could become smallpox free even when half or less of the population bore scars of primary vaccination [11]. This observation was soon confirmed in other countries of western Africa [12][13][14], India, Brazil, and Indonesia.…”
Section: Surveillance In the Smallpox Programmentioning
confidence: 99%
“…Furthermore, smallpox was eradicated using a form of outbreak control raising the possibility that a focus on controlling measles outbreaks might lead to similar success. 10,11 The smallpox eradication strategy focused on surveillance and containment. Cases were detected through surveillance and were isolated to prevent further transmission.…”
Section: Measles-1969 -1977mentioning
confidence: 99%