Selective embolization of thyroid arteries as a preresective and palliative treatment of thyroid cancer

Dedecjus, Marek; Tazbir, Józef; Kaurzel, Zbigniew; Lewiński, Andrzej; Stróżyk, Grzegorz; Brzeziński, Jan

doi:10.1677/erc-07-0011

Cited by 26 publications

(23 citation statements)

References 16 publications

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“…Similarly, peak fT4 level was noted 3 days and fT3 level 7 days after embolization in present results, with a gradual normalization reached after 1 month. These observations are in agreement with these obtained by Xiao et al [2], Zhao et al [34, 37], and Dedecjus et al [29]. This phenomenon may be explained by the destruction of thyroid parenchyma due to acute ischemia and necrosis of glandular tissue.…”

Section: Discussionsupporting

confidence: 93%

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The calcium–phosphate balance, modulation of thyroid autoimmune processes and other adverse effects connected with thyroid arterial embolization

et al. 2013

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In search of new treatment options for thyroid diseases, when conventional procedures are ineffective, contraindicated or associated with serious side effects, safety of thyroid arteries embolization in the treatment of particular thyroid diseases was evaluated. The study included eight subjects with retrosternal toxic goiter, six patients affected by Graves’ disease, five cases of retrosternal non-toxic goiter, two subjects with post-amiodarone hyperthyroidism, and one patient with severe thyroid-related orbitopathy, who underwent selective embolization of thyroid arteries. The study assessed and compared calcium–phosphate balance, modulation of thyroid autoimmunity and the presence of different side effects in patients who underwent the procedure. In addition, the serum concentrations of thyroid hormones, anti-thyroid autoantibodies and thyroid volume have been measured. Five of all enrolled subjects (22.7 %) experienced transient, not clinically relevant hypocalcaemia with no need for calcium supplementation. There were no significant changes in serum calcium levels in patients after embolization of both inferior thyroid arteries. The transient side effects associated with the treatment were neck pain and a slight increase in body temperature. Noted high concentration of free thyroid hormones immediately after the procedure was not accompanied by worsening of symptoms or signs of thyrotoxicosis. In patients with Graves’ disease, a significant decrease in thyrotropin receptor antibodies level was observed. Thyroid arterial embolization does not disturb permanently calcium–phosphate balance, modulates positively thyroid autoimmune processes and is associated with no serious post-procedure side effects. Hence, it may be considered as a safe and effective treatment modality for selected thyroid disorders.

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Section: Discussionsupporting

confidence: 93%

“…However, only few medical centers provided data about the possible advantages of arterial embolization in endocrinology [2, 25, 26, 29–32, 34]. …”

Section: Discussionmentioning

confidence: 99%

The calcium–phosphate balance, modulation of thyroid autoimmune processes and other adverse effects connected with thyroid arterial embolization

et al. 2013

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“…These include cancer vaccination therapy (31), photodynamic therapy (34), cryotherapy (35, 36), chemo-embolization (37), and immunotherapy (38). Despite the abundance of these alternative treatment modalities, their application to esophageal cancer has been slow.…”

Section: Discussionmentioning

confidence: 99%

Adenoviral-Based Immunotherapy Provides Local Disease Control in an Orthotopic Murine Model of Esophageal Cancer

Quatromoni¹,

Predina²,

Bhojnagarwala³

et al. 2014

Journal of Immunotherapy

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Despite recent advances in the development of novel therapies, esophageal carcinoma remains an aggressive cancer associated with a poor prognosis. The lack a high throughput, reproducible syngeneic animal model that replicates human disease is partly responsible for the paucity of novel therapeutic approaches. In this report, we present the first successful syngeneic, orthotopic model for esophageal cancer. This model was used to test an established adenoviral-based tumor vaccine. We utilized a murine esophageal cancer cell line established from the EDL2-cyclin D1;p53−/− mouse that was transduced to express a viral tumor antigen, the Human Papilloma Virus (HPV) E7 protein. The tumor was established in its natural microenvironment at the gastroesophageal (GE) junction. Tumor growth was consistent and reproducible. An adenoviral vaccine to E7 (Ad.E7) induced an E7-specific population of functionally active CD8+ T cells which trafficked into the tumors and retained cytotoxicity. Ad.E7 vaccination reduced local tumor growth and prolonged overall survival. These findings suggest that orthotopic tumor growth is a reasonable preclinical model to validate novel therapies.

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“…Surgery should therefore be performed soon (i.e. within 24-36 h) after embolisation with particles [ 25 ] .…”

Section: Thyroid Gland Tumoursmentioning

confidence: 99%

Head and Neck Vascular Lesions

Byrne

2011

Tutorials in Endovascular Neurosurgery and Interventional Neuroradiology

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Selective embolization of thyroid arteries as a preresective and palliative treatment of thyroid cancer

Cited by 26 publications

References 16 publications

The calcium–phosphate balance, modulation of thyroid autoimmune processes and other adverse effects connected with thyroid arterial embolization

The calcium–phosphate balance, modulation of thyroid autoimmune processes and other adverse effects connected with thyroid arterial embolization

Adenoviral-Based Immunotherapy Provides Local Disease Control in an Orthotopic Murine Model of Esophageal Cancer

Head and Neck Vascular Lesions

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