2009
DOI: 10.1016/j.neuroscience.2009.09.032
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Selective effects of neonatal handling on rat brain N-methyl-d-aspartate receptors

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Cited by 24 publications
(15 citation statements)
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“…Yet, NR-1, NR-2A, and NR-2B expression was decreased in PFC while unaffected in amygdala (Roceri et al, 2002; Wilber et al, 2009). However, levels of NR-2B in amygdala were increased in female, but not male rats (Stamatakis et al, 2009). Further, female, but not male rats, with a similar early life experience showed decreased nitric oxide (NO) production in hippocampus (Noschang et al, 2010).…”
Section: Enduring Hormonal and Neural Effects Of Early Life Manipmentioning
confidence: 96%
See 1 more Smart Citation
“…Yet, NR-1, NR-2A, and NR-2B expression was decreased in PFC while unaffected in amygdala (Roceri et al, 2002; Wilber et al, 2009). However, levels of NR-2B in amygdala were increased in female, but not male rats (Stamatakis et al, 2009). Further, female, but not male rats, with a similar early life experience showed decreased nitric oxide (NO) production in hippocampus (Noschang et al, 2010).…”
Section: Enduring Hormonal and Neural Effects Of Early Life Manipmentioning
confidence: 96%
“…Prolonged separation also lowered hippocampal levels of two NMDA receptor subunits, NR-2A and NR-2B, but did not affect levels of NR-1 or any subunit in cortex (Pickering et al, 2006; Roceri et al, 2002). Brief manipulations increased NR-2B levels in dorsal CA1 and CA3 regions but did not affect NR-1 or NR-2A levels (Stamatakis et al, 2009). Yet, NR-1, NR-2A, and NR-2B expression was decreased in PFC while unaffected in amygdala (Roceri et al, 2002; Wilber et al, 2009).…”
Section: Enduring Hormonal and Neural Effects Of Early Life Manipmentioning
confidence: 99%
“…For example, in adult offspring of mothers exposed to stress during gestation, mRNA expression levels of the NR1 subunit were reduced and NR2A increased in prefrontal cortex (Kinnunen et al 2003), whereas in other studies of adult rats that had been exposed to maternal separation stress, both NR2A (Roceri et al 2002) and NR2B (Pickering et al 2006;Roceri et al 2002) subunit mRNA were downregulated in hippocampus, but with little or no effect in prefrontal cortex. In contrast, 'positive' exposures, such as early handling or increased mother-pup interactions in the form of licking grooming and arched-back nursing elevated levels of NR1, NR2A and NR2B subunits in the hippocampus (Bredy et al 2004;Liu et al 2000;Stamatakis et al 2009). …”
Section: Glutamate Nmda Receptorsmentioning
confidence: 97%
“…Using an infantile stimulation procedure capable of assessing the contribution of the tactile somatosensory component separately, Burton et al (2006) showed that prepulse inhibition of the startle reflex is enhanced too, an even more elemental cognitive task than the previous ones, which provides a measure of involuntary attentional capturing independent of locomotor activity; thus, tactile stimulation has direct access to the brain substrates underlying attentional filtering (Burton et al, 2006); it also has selective effects on hipocampal-NMDA receptors (and in other limbic and cortical structures: Stamatakis et al, 2009) and it augments hippocampal long-term potentiation in young rats (Wilson et al, 1986). Therefore, the improvements in elemental phenomena such as sensory motor gating, latent inhibition, and associative learning can be taken as evidence that a core cognitive process could have been targeted by early handling, the changes in which could underlie at least in part some of the motivational and affective differences observed between H and NH rats, including R&T.…”
Section: Early Handling Cognition Emotionality and Playmentioning
confidence: 99%