“…Stimulation of NMDARs results in, at least in part, the activation of nNOS. The LC region contains NMDAR (Allgaier et al, 2001;Shaw et al, 1992;Van Bockstaele and Colago, 1996), neuronal nitric oxide synthase (nNOS)-positive neurons (Cuellar et al, 2000;Karolewicz et al, 2004;Xu et al, 1994), and guanosine 3 0 ,5 0 cyclic monophosphate (cGMP) (Vulliemoz et al, 1999;Xu et al, 1998), suggesting the existence of a glutamate/nitrergic transduction pathway. The exact cellular localization of these glutamate/nitrergic signaling proteins within the human LC is still unknown.…”