Selective detection of sulfur-containing compounds by gas chromatography/chemical reaction interface mass spectrometry

Moini, Mehdi; Chace, Donald H.; Abramson, Fred P.

doi:10.1016/1044-0305(91)80052-9

Cited by 20 publications

(6 citation statements)

References 12 publications

(19 reference statements)

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“…Hydrogen chloride has proved to be an e †ective reaction gas for selective detection of sulfur-containing compounds in complex mixtures. 24 Since selenium is in the same group of the Periodic Table as sulfur and exhibits many similar chemical properties, HCl was examined with regard to selenium detection. In the HClcontaining helium plasma, selenium-containing compounds are produced in the ion source of the mass spectrometer as 80SeCl`at m/z 115, the most selective selenium ion, and HCN`at m/z 27, the non-selective carbon ion,24 which is used to detect all organic compounds.…”

Section: Chemistrymentioning

confidence: 99%

Selective Detection of Selenium in Water Utilizing Chemical Reaction Interface Mass Spectrometry†

Moini

Perez³

et al. 1997

J. Mass Spectrom.

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Gas chromatography/chemical reaction interface mass spectrometry (GC/CRIMS) is shown to be a successful selective method for the detection of selenium‐containing compounds. Two reaction gases, sulfur dioxide (SO2) and hydrogen chloride (HCl), were examined in order to optimize selectivity and sensitivity. A high degree of selectivity was obtained with SO2 as a reaction gas; however, the detection limit of 80SeO3+ at m/z 128 (the most sensitive ion for the SO2‐containing plasma) was only 3 ng μl‐1. HCl gas, which had been shown to be a good reaction gas for sulfur‐containing compounds, was also shown to be an excellent reaction gas for selenium‐containing compounds. In the HCl‐containing plasma, 80SeCl+ at m/z 115 was the most sensitive and selective ion for the detection of selenium‐containing compounds. Selectivity was demonstrated by using mixtures of selenium‐containing and non‐selenium‐containing compounds. The utility of GC/CRIMS as a method for the selective detection of selenium‐containing compounds was demonstrated with a variety of selenium complexes that were formed by the addition of selective selenium complexing agents to selenium‐containing water. The detection limit of selenium in water was ∽62 pg and the linear dynamic range spanned at least two orders of magnitude (620 pg μl‐1–308 ng μl‐1).

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Section: Chemistrymentioning

confidence: 99%

Selective Detection of Selenium in Water Utilizing Chemical Reaction Interface Mass Spectrometry†

Moini

Perez³

et al. 1997

J. Mass Spectrom.

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“…The CRIMS chemistry and the general characteristics of optimization have been described in previous publications [2,7,9]. In this article, we emphasize those technically important details that have not been fully described.…”

Section: Optimization Of Operating Conditionsmentioning

confidence: 99%

“…Isotopic enrichments as low as 0.0044 atom % excess for 15N can be measured [10]. Detection limits below 100 pg for sulfur-and chlorine-containing compounds have been achieved [7,9].…”

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confidence: 98%

“…CRIM5 combines selective detection of elements and their isotopes and conventional mass spectrometry in a single system involving few modifications to the instrumentation. Selective detection of 2H , 13 C, 14 C, 15N, S, and CI has been reported [2][3][4][5][6][7][8][9][10][11][12]. The range of analytes includes drugs and drug metabolites, environmentally important substances, and endogenous compounds.…”

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confidence: 99%

“…The useful species are CO 2, NO, and HCl. These three products show sensitive, selective, and linear detection characteristics and provide good isotopic information [2,3,5,[7][8][9][10][11][12]. Water is not a good analytical species because of adsorption, reactivity, and exchange.…”

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Implementation of the chemical reaction interface mass spectrometry technique on a Hewlett-Packard mass-selective detector

Song

Kusmierz

Abramson

et al. 1994

J. Am. Soc. Mass Spectrom.

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A microwave-powered chemical reaction interface has been installed in a Hewlett-Packard gas chromatograph-mass spectrometer (GC-MS) system (5890 IT gas chromatograph-S971 mass-selective detector). The technical details and optimization strategies are discussed. The evaluation of this new setup is presented, showing detection limits of 1 ng of (13)C-, (15)N-, and Cl-containing compounds with signal-to-noise ratios greater than or egual to 3. Selective detection was evaluated with a urine sample from a dog dosed with (15)N3-midazolam that had been previously analyzed by using a differentially pumped research-level quadrupole mass spectrometer. The results show that the detection of (15)N and Cl remains highly selective and the mass-selective detector gives comparable sensitivity to the larger instrument when the latter is operating over a conventional mass range. The capability for chemical reaction interface mass spectrometry can be easily accomplished with an inexpensive GC-MS system.

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Selective detection and characterization of chlorine- and bromine-containing compounds in complex mixtures using microwave-induced plasma/chemical reaction interface mass spectrometry

Morré

Moini

1992

Biol. Mass Spectrom.

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In the environmental and pharmacological sciences, it is important to selectively detect chlorine-and brominecontaining compounds in complex mixtures. Currently, a new technique called microwave-induced plasma/chemical reaction interface mass speetrometry (MIP/CRIMS) is being used as a selective detector of elements and stable isotopes. This technique, which involves postcolumn reactions (a reaction interface), includes a low-pressure microwave-induced helium plasma (MIP) to which a reaction gas is added. Effluents of a chromatographic column that enter this reaction interface are converted into small stable neutrals. The mass spectra of these neutrals will identify and quantify the elements and isotopes of interest. Once the retention times of the peaks of interest are obtained, their full mass spectra can be acquired by repeating the experiment with the MIP OK This method combines the sensitivity of a halogen specific detector with the compound identification of mass spectrometry. In this study, SO2 has been found highly effective as a reaction gas for selective detection of chlorine-and brominecontaining compounds using GC/MIP/CRIMS. Detection limits of 10 pg and 1 ng, and dynamic range of at least four and two orders of magnitude, were achieved for chlorine-and bromine-containing compounds, respectively. The selective detection of chlorinated compounds in complex mixtures is demonstrated by using a mixture of non-chlorinated compounds and polychlorinated biphenyls, and by selective detection of triclopyr (a chlorinated herbicide) in extracts of leaves of garden bean (Phaseofus vulgaris var. Topcrop).

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Selective detection of sulfur-containing compounds by gas chromatography/chemical reaction interface mass spectrometry

Cited by 20 publications

References 12 publications

Selective Detection of Selenium in Water Utilizing Chemical Reaction Interface Mass Spectrometry†

Selective Detection of Selenium in Water Utilizing Chemical Reaction Interface Mass Spectrometry†

Implementation of the chemical reaction interface mass spectrometry technique on a Hewlett-Packard mass-selective detector

Selective detection and characterization of chlorine- and bromine-containing compounds in complex mixtures using microwave-induced plasma/chemical reaction interface mass spectrometry

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