Selective Depletion of Alloreactive T Cells and Study of Anti-Tumor Activity of Specific T Cell Clones in Patients with Leukemia and Renal Carcinoma

Matějková, Eva; Hroteková, Zuzana; Kyjovská, Drahomíra; Michálek, Jaroslav; Vidláková, Petra

doi:10.1016/j.clim.2007.03.482

Cited by 2 publications

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“…Several therapies that are effective in preventing GVHD usually lead to reduced graft- versus -leukaemia activity (GVL), which is the ability of donor-derived infused lymphocytes in a haematopoietic stem cell-transplanted patient to react against leukemic cells, invalidating their effective applications [50,51,52,53]. Graft- versus -host disease typically correlates with desired GVL reactivity [54,55,56].…”

Section: Resultsmentioning

confidence: 99%

Lithothamnion muelleri Controls Inflammatory Responses, Target Organ Injury and Lethality Associated with Graft-versus-Host Disease in Mice

et al. 2013

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Lithothamnion muelleri (Hapalidiaceae) is a marine red alga, which is a member of a group of algae with anti-inflammatory, antitumor, and immunomodulatory properties. The present study evaluated the effects of treatment with Lithothamnion muelleri extract (LM) in a model of acute graft-versus-host disease (GVHD), using a model of adoptive splenocyte transfer from C57BL/6 donors into B6D2F1 recipient mice. Mice treated with LM showed reduced clinical signs of disease and mortality when compared with untreated mice. LM-treated mice had reduced tissue injury, less bacterial translocation, and decreased levels of proinflammatory cytokines and chemokines (interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), chemokine (C-C motif) ligand 2 (CCL2), chemokine (C-C motif) ligand 3 (CCL3) and chemokine (C-C motif) ligand 5 (CCL5)). The polysaccharide-rich fraction derived from LM could inhibit leukocyte rolling and adhesion in intestinal venules, as assessed by intravital microscopy. LM treatment did not impair the beneficial effects of graft-versus-leukaemia (GVL). Altogether, our studies suggest that treatment with Lithothamnion muelleri has a potential therapeutic application in GVHD treatment.

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Section: Resultsmentioning

confidence: 99%

Lithothamnion muelleri Controls Inflammatory Responses, Target Organ Injury and Lethality Associated with Graft-versus-Host Disease in Mice

et al. 2013

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“…Several approaches to reduce GvHD have focused on reducing the alloreactive T-cell component of the graft, by physically removing activated T cells [52–54], eliminating activated T cells by incorporation of 4,5-dibromorhodamine 123 and exposure to light [55], tolerizing donor T cells against host-type alloantigen [8,56], passively eliminating alloreactive T cells in mixed lympho cyte cultures with ‘third-party’ stimulators [57], or culturing with IL-2 and anti-CD3 to generate activated but ‘nonalloreactive’ donor T cells [58]. None of these approaches has been adopted as part of routine clinical practice due to incomplete ability to separate GvL from GvHD.…”

Section: Modifying/selecting T Cellsmentioning

confidence: 99%

Separating Graft-Versus-Leukemia From Graft-Versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplantation

Giver

et al. 2009

Immunotherapy

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Routine methods to maximize the graft-versus-leukemia (GvL) activity of allogeneic hematopoietic stem cell transplantation (HSCT) without the detrimental effects of graft-versus-host disease (GvHD) are lacking. Depletion or inhibition of alloreactive T cells is partially effective in preventing GvHD, but usually leads to decreased GvL activity. The current model for the pathophysiology of acute GvHD describes a series of immune pathways that lead to activation of donor T cells and inflammatory cytokines responsible for tissue damage in acute GvHD. This model does not account for how allotransplant can lead to GvL effects without GvHD, or how the initial activation of donor immune cells may lead to counter-regulatory effects that limit GvHD. In this review, we will summarize new findings that support a more complex model for the initiation of GvHD and GvL activities in allogeneic HSCT, and discuss the potential of novel strategies to enhance GvL activity of the transplant.

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Selective Depletion of Alloreactive T Cells and Study of Anti-Tumor Activity of Specific T Cell Clones in Patients with Leukemia and Renal Carcinoma

Cited by 2 publications

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Lithothamnion muelleri Controls Inflammatory Responses, Target Organ Injury and Lethality Associated with Graft-versus-Host Disease in Mice

Lithothamnion muelleri Controls Inflammatory Responses, Target Organ Injury and Lethality Associated with Graft-versus-Host Disease in Mice

Separating Graft-Versus-Leukemia From Graft-Versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplantation

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