Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but regulates neurorepair processes after experimental ischemic stroke
Eloïse Lemarchand,
Alba Grayston,
Raymond Wong
et al.
Abstract:Inflammation is a key contributor to stroke pathogenesis and drives exacerbated brain damage leading to poor outcomes in patients. Interleukin-1 (IL-1) is an important regulator of post-stroke inflammation, and blocking its actions is beneficial in pre-clinical stroke models and safe in the clinical setting. IL-1α and IL-1β are the two major IL-1 type 1 receptor (IL-1R1) agonists from the IL-1 family, and although the role of IL-1β in stroke has been extensively studied, the distinct roles of both isoforms, an… Show more
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