Selective deficits in attentional performance on the 5-choice serial reaction time task following pedunculopontine tegmental nucleus lesions

Inglis, Wendy L.; Olmstead, Mary C.; Robbins, Trevor W.

doi:10.1016/s0166-4328(01)00181-4

Cited by 101 publications

(69 citation statements)

References 59 publications

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“…Lesions of PPTg specifically impair global attention, and this effect could account for results previously interpreted as reflecting difficulties with associative learning (Inglis et al, 2001). Recent data show that PPTg cells respond less to poorly attended cues (Ivlieva and Timofeeva, 2003), suggesting that an attentional or arousal gate acts at this level.…”

Section: Discussionmentioning

confidence: 73%

“…At the behavioral level, lesions of PPTg impair attention (Inglis et al, 2001) and the learning of associations between a conditioned stimulus and a primary reward (Inglis et al, 1994(Inglis et al, , 2000. Furthermore, some evidence from recordings in cats suggest that PPTg neuronal responses to auditory stimuli may be context dependent (Dormont et al, 1998), indicating a degree of plasticity similar to that seen in DA cell responses to predicted rewards (Schultz, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Pan

Hyland²

2005

J. Neurosci.

182

170

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Midbrain dopamine (DA) neurons respond to sensory cues that predict reward. We tested the hypothesis that projections from the pedunculopontine tegmental nucleus (PPTg) are involved in driving this DA cell activity. First, the activity of PPTg and DA neurons was compared in a cued-reward associative learning paradigm. The majority of PPTg neurons showed phasic responses to the onset of sensory cues, at significantly shorter latency than DA cells, consistent with a PPTg-to-DA transmission of information. However, unlike DA cells, PPTg responses were almost entirely independent of whether signals were associated with rewards. Second, DA neuron responses to the cues were recorded in free-moving rats during reversible inactivation of the PPTg by microinfusion of local anesthetic. The results showed clear suppression of conditioned sensory responses of DA neurons after PPTg inactivation that was not seen after saline infusion or in non-DA cells. We propose that the PPTg relays information about the precise timing of attended sensory events, which is integrated with information about reward context by DA neurons.

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Pan

Hyland²

2005

J. Neurosci.

182

170

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“…The reasons underlying these different effects of nicotine on omissions in rodents have yet to be clearly defined. One possible explanation is that in rats, the lack of effect of nicotine on omissions may be due to a floor effect as baseline omissions are already o10%, whereas in mice they are approximately 20% (Inglis et al, 2001;Spratt et al, 2001). This difference in omission levels cannot be attributed simply to the fact that mice were tested in apparatus commonly used for rats, as when the apparatus was scaled down, omission levels were still about 20% (Humby et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Nicotine Improves Sustained Attention in Mice: Evidence for Involvement of the α7 Nicotinic Acetylcholine Receptor

Young

Finlayson

Spratt

et al. 2004

Neuropsychopharmacol

209

174

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In humans, nicotine has been shown to improve attention in both normal and impaired individuals. Observations in rats reflect some, but not all aspects of the nicotine-induced improvements in humans. To date these findings have not been replicated in mice. To examine the effect of nicotine on sustained attention in mice, we have established a version of the 5-choice serial reaction-time (5-CSR) task with graded levels of difficulty, based upon spatial displacement and a variable intertrial interval. Using this paradigm, microgram doses of nicotine produced a consistent reduction in the level of omissions and an improvement in proportion correct in normal mice. This improvement in sustained attention was made irrespectively of whether mice had previously received nicotine. In an attempt to elucidate which nicotinic acetylcholine receptor (nAChR) subtype(s) mediate this effect, we examined the performance of a7 nAChR knockout (KO) mice in the 5-CSR task. a7 nAChR KO mice not only acquired the task more slowly than their wild-type littermates, but on attaining asymptotic performance, they exhibited a higher level of omissions. In conclusion, by increasing the level of task difficulty, the performance of mice was maintained at sufficiently low levels to allow a demonstrable improvement in performance upon nicotine administration. Furthermore, as a7 KO mice are clearly impaired in the acquisition and asymptotic performance of this task, the a7 nAChR may be involved in mediating these effects of nicotine.

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“…In animal models, PPN lesions have been reported to impair attention, executive function, working memory and learning Inglis et al, 2000Inglis et al, , 2001Inglis and Winn 1995;Kozak et al, 2005;Garcia-Rill, 1991). High frequency PPN DBS in a non-human primate model had similar effects.…”

mentioning

confidence: 88%

Critical evaluation of the anatomical location of the Barrington nucleus: Relevance for deep brain stimulation surgery of pedunculopontine tegmental nucleus

et al. 2013

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Selective deficits in attentional performance on the 5-choice serial reaction time task following pedunculopontine tegmental nucleus lesions

Cited by 101 publications

References 59 publications

Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Nicotine Improves Sustained Attention in Mice: Evidence for Involvement of the α7 Nicotinic Acetylcholine Receptor

Critical evaluation of the anatomical location of the Barrington nucleus: Relevance for deep brain stimulation surgery of pedunculopontine tegmental nucleus

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