Selective dechlorination of polychlorofluoroaromatic compounds: preparation of 1,3,5-trifluorobenzene

Metal-Mediated Reductive Hydrodehalogenation of Organic Halides

“…The vapor-phase dechlorination of a mixture of the isomers of trichlorotrifluorobenzene, by hydrogen on 2% Pd/C catalyst and at high temperatures (250 and 300 °C), proceeded with acceptable or good conversions but with a low yield of the desired trifluorobenzenes due to considerable defluorination. 370 However, smooth and selective reductive dechlorination leading to the formation of a mixture of trifluorobenzenes (100% conversion) was achieved when the reaction was conducted in the liquid phase using 1-butanol as solvent, 2% Pd/C as catalyst, and sodium acetate as hydrogen chloride acceptor at 80-90 °C, with only 0.1% reductive defluorination being detected.…”