Selective Damage of Trigeminal Aδ Fibres in Raeder'S Syndrome Following Dissection of the ICA Detected by A Nociceptive Blink Reflex

Katsarava, Zaza; Frings, Markus; Kaube, Holger; Hc, Diener; Limmroth, Volker

doi:10.1046/j.1468-2982.2002.00322.x

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…The nBR is elicited by a novel concentric stimulating electrode, which by virtue of its new geometry predominantly stimulates cutaneous superficial nociceptive fibres without depolarizing more deeply lying non‐nociceptive fibres (5). Therefore, the nBR is highly sensitive to changes in trigeminal nociception (6).…”

Section: Introductionmentioning

confidence: 99%

Abnormal Habituation of ‘nociceptive’ Blink Reflex in Migraine-Evidence for Increased Excitability of Trigeminal Nociception

et al. 2003

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We studied the habituation of the 'nociceptive' blink reflex (nBR) in 15 healthy subjects and 17 migraine patients interictally as well as during unilateral migraine headache within six hours of onset and after treatment. In healthy volunteers the mean regression coefficient (MRC) was - 3.9 following right sided and - 4.9 left sided stimulation. This equals an amplitude loss of 19.5% (5 x -3.9) and 24.5% (5 x -4.9), respectively, across five consecutive sweeps. An augmentation of nBR responses was found in migraine patients interictally: MRC = 3.3 following stimulation of the headache side (HA) and MRC = 4.0 of the non-headache side (non-HA). The differences were statistically significant (anova: d.f. = 1, F = 25.8, P < 0.001). During the migraine attack MRCs were negative both before (-5.0, HA and - 4.0, non-HA) and after treatment (-2.6, HA and - 1.9 non-HA) and significantly differed from those outside the migraine attack (anova: d.f. = 2, F = 12.4, P < 0.001). The demonstrated lack of habituation of the nBR responses indicates an abnormal trigeminal nociceptive processing in migraine patients outside the migraine attack.

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Section: Introductionmentioning

confidence: 99%

Abnormal Habituation of ‘nociceptive’ Blink Reflex in Migraine-Evidence for Increased Excitability of Trigeminal Nociception

et al. 2003

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“…This reduction is most likely caused by the unspecific habituation process as shown previously by Katsarava et al . (3). Therefore, although it is not known to which extent the placebo effect may be larger during acute migraine it is unlikely that it could account for the whole extent of the observed reduction.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, depolarization is limited to the superficial layer of the dermis containing nociceptive A-delta fibres but does not reach the deeper, A-beta fibre containing, layers. The nBR has been shown to be highly sensitive to changes in trigeminal nociception (5). Using the nBR a temporary facilitation of the trigeminal nociceptive system could be detected during acute migraine attacks but not interictally (6).…”

Section: Introductionmentioning

confidence: 99%

Differences of Anti-Nociceptive Mechanisms of Migraine Drugs on the Trigeminal Pain Processing during and Outside Acute Migraine Attacks

et al. 2004

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The aim of this study was to investigate central anti-nociceptive mechanisms of i.v. acetylsalicylic acid (ASA) and oral zolmitriptan (ZOL) in migraine patients and healthy subjects using the 'nociceptive' blink reflex (nBR). Twenty-eight migraine patients received ASA (n = 14, 1000 mg i.v) or ZOL (n = 14, 5 mg p.o) during the acute migraine attack and interictally. Thirty healthy subjects received either ASA or ZOL vs. placebo using a double blind cross over design. nBR was recorded in all patients and subjects before, 60 and 90 min after treatment. ASA and ZOL did not inhibit nBR responses in healthy subjects. Both ASA and ZOL suppressed nBR responses (ASA by 68%, ZOL by 78%) only during the acute attack but not interictally. The data suggest, that the anti-nociceptive effects of migraine drugs on the trigeminal nociceptive processing are different during and outside an acute migraine attack.

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Neurophysiological assessment of trigeminal nerve reflexes in disorders of central and peripheral nervous system

Valls‐Solé

2005

Clinical Neurophysiology

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Selective Damage of Trigeminal Aδ Fibres in Raeder'S Syndrome Following Dissection of the ICA Detected by A Nociceptive Blink Reflex

Cited by 6 publications

References 7 publications

Abnormal Habituation of ‘nociceptive’ Blink Reflex in Migraine-Evidence for Increased Excitability of Trigeminal Nociception

Abnormal Habituation of ‘nociceptive’ Blink Reflex in Migraine-Evidence for Increased Excitability of Trigeminal Nociception

Differences of Anti-Nociceptive Mechanisms of Migraine Drugs on the Trigeminal Pain Processing during and Outside Acute Migraine Attacks

Neurophysiological assessment of trigeminal nerve reflexes in disorders of central and peripheral nervous system

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